BACKGROUND: Recent literature reviews have questioned hostility as a risk factor for heart disease. However, controversy persists due to the rarity of large-scale prospective cohort studies of initially healthy populations. METHODS: We prospectively investigated the association between hostility and cardiovascular (and all-cause) mortality among 20,550 men and women, 41-80 years of age, participating in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk), United Kingdom study. Participants were recruited by post from general practice age-sex registers and subsequently attended health checks that included the assessment of coronary disease risk factors. Hostility assessment was completed by postal questionnaire. RESULTS: During mean follow-up of 6 years, 1284 deaths were recorded including 481 from cardiovascular disease (CVD). Hostility was not associated with CVD mortality, after adjustment for age and prevalent disease, in either men (rate ratio for a 1 SD decrease in hostility score, representing increased hostility, 1.09; 95% confidence interval 0.98-1.22) or in women (rate ratio 1.00; 95% confidence interval 0.86-1.26). Subgroup analysis suggested hostility may be associated with CVD mortality (independent of age, prevalent disease and cigarette smoking) for participants reporting very high hostility and for those aged less than 60 years. CONCLUSIONS: Hostility was not associated with an increased risk of cardiovascular mortality in this population study of older adults.
BACKGROUND: Recent literature reviews have questioned hostility as a risk factor for heart disease. However, controversy persists due to the rarity of large-scale prospective cohort studies of initially healthy populations. METHODS: We prospectively investigated the association between hostility and cardiovascular (and all-cause) mortality among 20,550 men and women, 41-80 years of age, participating in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk), United Kingdom study. Participants were recruited by post from general practice age-sex registers and subsequently attended health checks that included the assessment of coronary disease risk factors. Hostility assessment was completed by postal questionnaire. RESULTS: During mean follow-up of 6 years, 1284 deaths were recorded including 481 from cardiovascular disease (CVD). Hostility was not associated with CVD mortality, after adjustment for age and prevalent disease, in either men (rate ratio for a 1 SD decrease in hostility score, representing increased hostility, 1.09; 95% confidence interval 0.98-1.22) or in women (rate ratio 1.00; 95% confidence interval 0.86-1.26). Subgroup analysis suggested hostility may be associated with CVD mortality (independent of age, prevalent disease and cigarette smoking) for participants reporting very high hostility and for those aged less than 60 years. CONCLUSIONS: Hostility was not associated with an increased risk of cardiovascular mortality in this population study of older adults.
Authors: Cédric Lemogne; Hermann Nabi; Marie Zins; Sylvaine Cordier; Pierre Ducimetière; Marcel Goldberg; Silla M Consoli Journal: Psychother Psychosom Date: 2010-02-20 Impact factor: 17.659
Authors: Jonathan D Newman; Karina W Davidson; Jonathan A Shaffer; Joseph E Schwartz; William Chaplin; Susan Kirkland; Daichi Shimbo Journal: J Am Coll Cardiol Date: 2011-09-13 Impact factor: 24.094
Authors: Gonnie Klabbers; Hans Bosma; Gertrudis Ignatius Johannes Maria Kempen; Michaela Benzeval; Marjan Van den Akker; Jacques Theodorus Margaretha van Eijk Journal: J Behav Med Date: 2013-02-06
Authors: Lisa L Barnes; Carlos F Mendes de Leon; Julia L Bienias; Robert S Wilson; Susan A Everson-Rose; Denis A Evans Journal: Psychosom Med Date: 2009-05-29 Impact factor: 4.312
Authors: Hermann Nabi; Mika Kivimäki; Marie Zins; Marko Elovainio; Silla M Consoli; Sylvaine Cordier; Pierre Ducimetière; Marcel Goldberg; Archana Singh-Manoux Journal: Int J Epidemiol Date: 2008-02-08 Impact factor: 7.196