| Literature DB >> 15814249 |
Zohra Zili1, Souad Sfar, Hatem Fessi.
Abstract
Griseofulvin is an antifungal agent with poor solubility and low bioavailability. The aim of this work was to prepare poly-epsilon-caprolactone nanospheres and nanocapsules of griseofulvin by nanoprecipitation and to characterize them. Nanoparticles of griseofulvin were obtained with high encapsulation efficiency. The particle size was about 250-326 nm for nanospheres and 390-400 nm for nanocapsules. The dissolution rate of griseofulvin nanoparticles was higher than that of micronized griseofulvin therefore recourse to nanoencapsulation of griseofulvin should enhance its bioavailability and possibly its efficiency for the treatment of dermatomycosis.Entities:
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Year: 2005 PMID： 15814249 DOI： 10.1016/j.ijpharm.2005.01.020
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875