Literature DB >> 15812854

Functional analysis of the aureothin iterative type I polyketide synthase.

Jing He1, Christian Hertweck.   

Abstract

The modular-type polyketide synthase (PKS) that is involved in aureothin (aur) biosynthesis represents one of the first examples in which a single PKS module (AurA) is used in an iterative fashion. Here we report on the heterologous expression of an engineered AurAB fusion protein that unequivocally proves the iterative nature of AurA. In addition, point mutations reveal that aur PKS module 4 participates in polyketide biosynthesis despite its aberrant acyltransferase domain.

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Year:  2005        PMID： 15812854     DOI： 10.1002/cbic.200400333

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  16 in total

1.  Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation.

Authors:  Shiven Kapur; Brian Lowry; Satoshi Yuzawa; Sanketha Kenthirapalan; Alice Y Chen; David E Cane; Chaitan Khosla
Journal:  Proc Natl Acad Sci U S A       Date:  2012-02-27       Impact factor: 11.205

2.  Structures and biosynthesis of the pyridinopyrones, polyenepyrones from a marine-derived Streptomyces species.

Authors:  Takashi Fukuda; Eric D Miller; Benjamin R Clark; Ali Alnauman; Cormac D Murphy; Paul R Jensen; William Fenical
Journal:  J Nat Prod       Date:  2011-07-13       Impact factor: 4.050

3.  Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues.

Authors:  Martina Werneburg; Benjamin Busch; Jing He; Martin E A Richter; Longkuan Xiang; Bradley S Moore; Martin Roth; Hans-Martin Dahse; Christian Hertweck
Journal:  J Am Chem Soc       Date:  2010-08-04       Impact factor: 15.419

4.  Pyran formation by an atypical CYP-mediated four-electron oxygenation-cyclization cascade in an engineered aureothin pathway.

Authors:  Martin Richter; Benjamin Busch; Keishi Ishida; Bradley S Moore; Christian Hertweck
Journal:  Chembiochem       Date:  2012-09-07       Impact factor: 3.164

Review 5.  The type I fatty acid and polyketide synthases: a tale of two megasynthases.

Authors:  Stuart Smith; Shiou-Chuan Tsai
Journal:  Nat Prod Rep       Date:  2007-07-02       Impact factor: 13.423

6.  Functional dissection of a multimodular polypeptide of the pikromycin polyketide synthase into monomodules by using a matched pair of heterologous docking domains.

Authors:  John Yan; Shuchi Gupta; David H Sherman; Kevin A Reynolds
Journal:  Chembiochem       Date:  2009-06-15       Impact factor: 3.164

Review 7.  Iterative polyketide biosynthesis by modular polyketide synthases in bacteria.

Authors:  Haotong Chen; Liangcheng Du
Journal:  Appl Microbiol Biotechnol       Date:  2015-11-09       Impact factor: 4.813

8.  Evidence for an iterative module in chain elongation on the azalomycin polyketide synthase.

Authors:  Hui Hong; Yuhui Sun; Yongjun Zhou; Emily Stephens; Markiyan Samborskyy; Peter F Leadlay
Journal:  Beilstein J Org Chem       Date:  2016-10-11       Impact factor: 2.883

9.  Reconstitution of the myxothiazol biosynthetic gene cluster by Red/ET recombination and heterologous expression in Myxococcus xanthus.

Authors:  Olena Perlova; Jun Fu; Silvia Kuhlmann; Daniel Krug; A Francis Stewart; Youming Zhang; Rolf Müller
Journal:  Appl Environ Microbiol       Date:  2006-09-22       Impact factor: 4.792

10.  Novel intermolecular iterative mechanism for biosynthesis of mycoketide catalyzed by a bimodular polyketide synthase.

Authors:  Tarun Chopra; Srijita Banerjee; Sarika Gupta; Gitanjali Yadav; Swadha Anand; Avadhesha Surolia; Rajendra P Roy; Debasisa Mohanty; Rajesh S Gokhale
Journal:  PLoS Biol       Date:  2008-07-08       Impact factor: 8.029
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