Literature DB >> 1580922

Tianeptine, a specific serotonin uptake enhancer, decreases ethanol intake in rats.

M Daoust1, P Compagnon, E Legrand, E Mocaër.   

Abstract

The effect on ethanol intake of the selective 5-HT uptake enhancer tianeptine was examined in rats and compared with that of fluoxetine, a specific 5-HT uptake inhibitor. Both treatments significantly decreased ethanol intake (54% by tianeptine and 57% by fluoxetine). Fluoxetine also decreased food intake whereas tianeptine did not. Body weight was decreased by 12.5% in fluoxetine-treated rats but was not modified by tianeptine. It is proposed that tianeptine has a specific action on ethanol intake, possibly related to its effect on serotonin function.

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Year:  1992        PMID： 1580922

Source DB:  PubMed          Journal:  Alcohol Alcohol        ISSN： 0735-0414            Impact factor:   2.826


  4 in total

Review 1.  Tianeptine: a review of its use in depressive disorders.

Authors:  A J Wagstaff; D Ormrod; C M Spencer
Journal:  CNS Drugs       Date:  2001       Impact factor: 5.749

Review 2.  Role of the serotonergic system in alcohol dependence: from animal models to clinics.

Authors:  Youssef Sari; Verity R Johnson; Jason M Weedman
Journal:  Prog Mol Biol Transl Sci       Date:  2011       Impact factor: 3.622

3.  CaMKIIα-GluA1 Activity Underlies Vulnerability to Adolescent Binge Alcohol Drinking.

Authors:  Abigail E Agoglia; Sarah E Holstein; Grant Reid; Clyde W Hodge
Journal:  Alcohol Clin Exp Res       Date:  2015-08-06       Impact factor: 3.455

Review 4.  Tianeptine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depression and coexisting anxiety and depression.

Authors:  M I Wilde; P Benfield
Journal:  Drugs       Date:  1995-03       Impact factor: 9.546
  4 in total

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