| Literature DB >> 1580866 |
P Marlton1, K Taylor, S Elliott, J McCormack.
Abstract
A 60-year-old part Aboriginal woman was observed to develop severe neutropenia and a large granular lymphocyte (LGL) proliferation five years after the diagnosis of systemic lupus erythematosus (SLE). Monoclonality of the CD3+, CD4-, CD8+ LGL population was confirmed using the novel approach of X-linked restriction fragment length polymorphism (RFLP) analysis. Indeterminate HTLV-I serology was present. The patient responded to steroid therapy. LGL proliferation in the setting of SLE and the use of X-linked RFLP analysis to define LGL clonality have not previously been reported.Entities:
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Year: 1992 PMID： 1580866 DOI： 10.1111/j.1445-5994.1992.tb01711.x
Source DB: PubMed Journal: Aust N Z J Med ISSN： 0004-8291