Literature DB >> 15808479

A fluorimetric assay for the spontaneous release of an N7-alkylguanine residue from duplex DNA.

Ekaterina Shipova1, Kent S Gates.   

Abstract

A fluorimetric assay for monitoring depurination of the N7-alkylguanine adduct derived from the anticancer natural product leinamycin is described. This general approach could potentially provide the foundation for a high throughput assay that detects DNA-alkylating agents or a convenient continuous fluorimetric assay for base excision repair enzymes.

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Year:  2005        PMID： 15808479     DOI： 10.1016/j.bmcl.2005.02.058

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.

Authors:  Velliyur Viswesh; Allison M Hays; Kent Gates; Daekyu Sun
Journal:  Bioorg Med Chem       Date:  2012-05-23       Impact factor: 3.641

Review 2.  An overview of chemical processes that damage cellular DNA: spontaneous hydrolysis, alkylation, and reactions with radicals.

Authors:  Kent S Gates
Journal:  Chem Res Toxicol       Date:  2009-11       Impact factor: 3.739

3.  Synthesis and characterization of a small analogue of the anticancer natural product leinamycin.

Authors:  Kripa Keerthi; Anuruddha Rajapakse; Daekyu Sun; Kent S Gates
Journal:  Bioorg Med Chem       Date:  2012-10-27       Impact factor: 3.641

4.  Thiol-activated DNA damage by α-bromo-2-cyclopentenone.

Authors:  Mostafa I Fekry; Nathan E Price; Hong Zang; Chaofeng Huang; Michael Harmata; Paul Brown; J Scott Daniels; Kent S Gates
Journal:  Chem Res Toxicol       Date:  2011-01-20       Impact factor: 3.739

5.  Chemical structure and properties of interstrand cross-links formed by reaction of guanine residues with abasic sites in duplex DNA.

Authors:  Michael J Catalano; Shuo Liu; Nisana Andersen; Zhiyu Yang; Kevin M Johnson; Nathan E Price; Yinsheng Wang; Kent S Gates
Journal:  J Am Chem Soc       Date:  2015-03-11       Impact factor: 15.419

6.  Characterization of DNA damage induced by a natural product antitumor antibiotic leinamycin in human cancer cells.

Authors:  Velliyur Viswesh; Kent Gates; Daekyu Sun
Journal:  Chem Res Toxicol       Date:  2010-01       Impact factor: 3.739

7.  Possible chemical mechanisms underlying the antitumor activity of S-deoxyleinamycin.

Authors:  Santhosh Sivaramakrishnan; Kent S Gates
Journal:  Bioorg Med Chem Lett       Date:  2007-11-28       Impact factor: 2.823

Review 8.  Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents.

Authors:  Joanna Klapacz; Lynn H Pottenger; Bevin P Engelward; Christopher D Heinen; George E Johnson; Rebecca A Clewell; Paul L Carmichael; Yeyejide Adeleye; Melvin E Andersen
Journal:  Mutat Res Rev Mutat Res       Date:  2015-12-02       Impact factor: 5.657

9.  The oxidatively induced DNA lesions 8,5'-cyclo-2'-deoxyadenosine and 8-hydroxy-2'-deoxyadenosine are strongly resistant to acid-induced hydrolysis of the glycosidic bond.

Authors:  Jacob A Theruvathu; Pawel Jaruga; Miral Dizdaroglu; P J Brooks
Journal:  Mech Ageing Dev       Date:  2007-06-27       Impact factor: 5.432

10.  The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product.

Authors:  Santhosh Sivaramakrishnan; Leonid Breydo; Daekyu Sun; Kent S Gates
Journal:  Bioorg Med Chem Lett       Date:  2012-04-12       Impact factor: 2.823
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