| Literature DB >> 15808470 |
B Narasimhulu Naidu1, Margaret E Sorenson, Joanne J Bronson, Michael J Pucci, Junius M Clark, Yasutsugu Ueda.
Abstract
The synthesis and antibacterial activity of a series of nocathiacin I derivatives (4-20) containing polar water solubilizing groups is described. Thiol-Michael adducts containing acidic polar groups have reduced antibacterial activity whereas those with basic polar groups have retained very good antibacterial activity.Entities:
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Year: 2005 PMID： 15808470 DOI： 10.1016/j.bmcl.2005.02.046
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823