Literature DB >> 15808465

Inosine substitutions demonstrate that intramolecular DNA quadruplexes adopt different conformations in the presence of sodium and potassium.

Antonina Risitano1, Keith R Fox.   

Abstract

We have examined the stability of fluorescently-labelled oligonucleotides that are based on the human telomeric repeat [(GGGTTA)(3)GGG], in which one of the guanines in turn is substituted with inosine. We show that the relative stability of the substitutions is different in the presence of sodium and potassium. The data for potassium suggest a parallel arrangement of the strands, while the sodium form is mixed parallel and antiparallel.

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Year:  2005        PMID： 15808465     DOI： 10.1016/j.bmcl.2005.02.050

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  22 in total

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2.  Distinct differences in metal ion specificity of RNA and DNA G-quadruplexes.

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3.  Structure of the human telomere in K+ solution: a stable basket-type G-quadruplex with only two G-tetrad layers.

Authors:  Kah Wai Lim; Samir Amrane; Serge Bouaziz; Weixin Xu; Yuguang Mu; Dinshaw J Patel; Kim Ngoc Luu; Anh Tuân Phan
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4.  G-register exchange dynamics in guanine quadruplexes.

Authors:  Robert W Harkness; Anthony K Mittermaier
Journal:  Nucleic Acids Res       Date:  2016-04-07       Impact factor: 16.971

Review 5.  Polymorphism of human telomeric quadruplex structures.

Authors:  Jixun Dai; Megan Carver; Danzhou Yang
Journal:  Biochimie       Date:  2008-03-08       Impact factor: 4.079

Review 6.  Stability and kinetics of G-quadruplex structures.

Authors:  Andrew N Lane; J Brad Chaires; Robert D Gray; John O Trent
Journal:  Nucleic Acids Res       Date:  2008-08-21       Impact factor: 16.971

7.  Evidence for Reverse Hoogsteen Hairpin Intermediates in the Photocrosslinking of Human Telomeric DNA Sequences.

Authors:  Chen Lu; Jillian E Smith-Carpenter; John-Stephen A Taylor
Journal:  Photochem Photobiol       Date:  2018-03-31       Impact factor: 3.421

8.  POT1-TPP1 Binding and Unfolding of Telomere DNA Discriminates against Structural Polymorphism.

Authors:  Michael R Mullins; Malligarjunan Rajavel; Wilnelly Hernandez-Sanchez; Maria de la Fuente; Sherri M Biendarra; Michael E Harris; Derek J Taylor
Journal:  J Mol Biol       Date:  2016-05-10       Impact factor: 6.151

9.  Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad.

Authors:  Kah Wai Lim; Patrizia Alberti; Aurore Guédin; Laurent Lacroix; Jean-François Riou; Nicola J Royle; Jean-Louis Mergny; Anh Tuân Phan
Journal:  Nucleic Acids Res       Date:  2009-08-19       Impact factor: 16.971

10.  QuadBase2: web server for multiplexed guanine quadruplex mining and visualization.

Authors:  Parashar Dhapola; Shantanu Chowdhury
Journal:  Nucleic Acids Res       Date:  2016-05-16       Impact factor: 16.971
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