Literature DB >> 15808451

Synthesis of the optical isomers of a new anticholinergic drug, penehyclidine hydrochloride (8018).

Xiang-Yu Han1, He Liu, Chun-He Liu, Bo Wu, Lan-Fu Chen, Bo-Hua Zhong, Ke-Liang Liu.   

Abstract

A practical diastereoselective synthetic method for 8018 enantiopure isomers is described. The intramolecular asymmetric epoxidation of mono-sulfonate 4 was applied for the execution of the synthesis of the key chiral building block for the first time. The isomers were obtained with 70-76% yields in 99-100% ee.

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Year:  2005        PMID： 15808451     DOI： 10.1016/j.bmcl.2005.02.071

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  21 in total

1.  Penehyclidine enhances the efficacy of tropisetron in prevention of PONV following gynecological laparoscopic surgery.

Authors:  Zhiming Zhang; Yuehong Zhuang; Fang Ouyang; Ansheng Zhang; Bin Zeng; Miaoning Gu
Journal:  J Anesth       Date:  2012-08-10       Impact factor: 2.078

2.  A Selective M1 and M3 Receptor Antagonist, Penehyclidine Hydrochloride, Exerts Antidepressant-Like Effect in Mice.

Authors:  Xiaojing Sun; Congcong Sun; Lingyan Zhai; Wei Dong
Journal:  Neurochem Res       Date:  2019-10-12       Impact factor: 3.996

3.  Effects of penehyclidine hydrochloride on the propofol dose requirement and Bispectral Index for loss of consciousness.

Authors:  Peng Liang; Yanju Zhang; Hai Yu; Bin Liu
Journal:  Int J Clin Exp Med       Date:  2014-08-15

4.  Rarely reported ocular complications following surgery to correct chronic suppurative otitis media.

Authors:  Xiaopan Lu; Yu Zhao; Dan Lu; Ping An; Yongbo Zheng; Xueling Qin; LiHong Wang; Joseph B Roberson
Journal:  Eur Arch Otorhinolaryngol       Date:  2011-05-28       Impact factor: 2.503

5.  Effect of penehyclidine hydrochloride on expressions of MAPK in mice with CLP-induced acute lung injury.

Authors:  Jia Zhan; Yongpan Liu; Zongze Zhang; Chang Chen; Kai Chen; Yanlin Wang
Journal:  Mol Biol Rep       Date:  2010-09-16       Impact factor: 2.316

6.  Effects of penehyclidine hydrochloride on rat intestinal barrier function during cardiopulmonary bypass.

Authors:  Ying-Jie Sun; Hui-Juan Cao; Qiang Jin; Yu-Gang Diao; Tie-Zheng Zhang
Journal:  World J Gastroenterol       Date:  2011-04-28       Impact factor: 5.742

7.  Effects of penehyclidine hydrochloride in small intestinal damage caused by limb ischemia-reperfusion.

Authors:  Yan Zhang; Yu-Fang Leng; Xing Xue; Yue Zhang; Tao Wang; Yu-Qing Kang
Journal:  World J Gastroenterol       Date:  2011-01-14       Impact factor: 5.742

8.  Effects of early administration of a novel anticholinergic drug on acute respiratory distress syndrome induced by sepsis.

Authors:  Hao Li; Zhaoxin Qian; Jianmin Li; Xiaotong Han; Min Liu
Journal:  Med Sci Monit       Date:  2011-11

Review 9.  Penehyclidine hydrochloride: a potential drug for treating COPD by attenuating Toll-like receptors.

Authors:  Hong-Tao Xiao; Zhi Liao; Rong-Sheng Tong
Journal:  Drug Des Devel Ther       Date:  2012-11-01       Impact factor: 4.162

10.  High postoperative serum cortisol level is associated with increased risk of cognitive dysfunction early after coronary artery bypass graft surgery: a prospective cohort study.

Authors:  Dong-Liang Mu; Li-Huan Li; Dong-Xin Wang; Nan Li; Guo-Jin Shan; Jun Li; Qin-Jun Yu; Chun-Xia Shi
Journal:  PLoS One       Date:  2013-10-15       Impact factor: 3.240
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