| Literature DB >> 15808313 |
Luciano Lobo Gatti1, Ellen Kris Fagundes e Souza, Kátia Ramos Leite, Eduardo Lemos de Souza Bastos, Luciano Roberto Vicentini, Luiz Carlos da Silva, Marília de Arruda Cardoso Smith, Spencer Luiz Marques Payão.
Abstract
Helicobacter pylori is an important human pathogen that causes chronic gastritis and is associated with development of peptic ulcer disease and gastric malignancies. The vacuolating cytotoxin (vacA), cagA gene, and babA2 gene are important virulence factor involving gastric diseases. Eighty-nine Helicobacter pylori-positive gastric biopsies were analyzed by polymerase chain reaction and Southern blotting for H. pylori detection and genotyping with primer pairs from each virulence gene. Fifty-three strains (59%) were common vacA genotype s1/m1, and only 14 (16%) were s2/m2, 12% of strains was found to have multiple infection. The cagA presence was detected in 48% (43 strains) and babA2 gene was detected in 44% of our H. pylori strains. We observed high percentage of s1/m1 strains with chronic gastritis and peptic ulcer and a significant correlation between cagA presence with the s1 allele and babA2 gene with chronic gastritis.Entities:
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Year: 2005 PMID： 15808313 DOI： 10.1016/j.diagmicrobio.2004.11.007
Source DB: PubMed Journal: Diagn Microbiol Infect Dis ISSN： 0732-8893 Impact factor: 2.803