Using stable isotopes to assess the bioavailability of minerals in food-fortification programs.

Food fortification with minerals is often undertaken without consideration of the bioavailability or nutrient-nutrient interactions related to its use. Stable isotopes provide a safe and accessible approach to providing direct evidence regarding these issues. Studies can be applied in all areas of the world and in all population groups. Mineral stable isotopes are safe and meet stringent ethical standards for use in children. Clinical studies in children allowing scientists, policy makers and the food industry to obtain data needed to understand how best to fortify foods to enhance the nutritional health of children of all ages. It is not necessary to have analytical mass spectrometry equipment available in each country where studies are performed. Rather, international collaborations can be developed to allow clinical studies to be performed in the field setting with analysis elsewhere if needed. The combination of isotope studies with field intervention trials may be beneficial.