Literature DB >> 15803146

Epigenetic regulation of protein tyrosine phosphatases: potential molecular targets for cancer therapy.

Samson T Jacob1, Tasneem Motiwala.   

Abstract

Promoter methylation-mediated silencing is a hallmark of many established tumor suppressor genes. This review focuses on the methylation and suppression of a receptor-type tyrosine phosphatase gene, PTPRO, in a variety of solid and liquid tumors. In addition, PTPRO exhibits many other characteristics of a bona fide tumor suppressor. Reactivation of genes silenced by methylation using inhibitors of DNA methyltransferases and histone deacetylases, and the potential application of PTPRO as a molecular target for cancer therapy have been discussed.

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Year:  2005        PMID： 15803146      PMCID： PMC3028596          DOI： 10.1038/sj.cgt.7700828

Source DB:  PubMed          Journal:  Cancer Gene Ther        ISSN： 0929-1903            Impact factor:   5.987


  70 in total

Review 1.  The history of cancer epigenetics.

Authors:  Andrew P Feinberg; Benjamin Tycko
Journal:  Nat Rev Cancer       Date:  2004-02       Impact factor: 60.716

Review 2.  Reversal of gene silencing as a therapeutic target for cancer--roles for DNA methylation and its interdigitation with chromatin.

Authors:  Stephen B Baylin
Journal:  Novartis Found Symp       Date:  2004

3.  Antineoplastic action of 5-aza-2'-deoxycytidine (Dacogen) and depsipeptide on Raji lymphoma cells.

Authors:  Sepideh Shaker; Mark Bernstein; Richard L Momparler
Journal:  Oncol Rep       Date:  2004-06       Impact factor: 3.906

4.  Identification of genes uniquely involved in frequent microsatellite instability colon carcinogenesis by expression profiling combined with epigenetic scanning.

Authors:  Yuriko Mori; Jing Yin; Fumiaki Sato; Anca Sterian; Lisa A Simms; Florin M Selaru; Karsten Schulmann; Yan Xu; Andreea Olaru; Suna Wang; Elena Deacu; John M Abraham; Joanne Young; Barbara A Leggett; Stephen J Meltzer
Journal:  Cancer Res       Date:  2004-04-01       Impact factor: 12.701

Review 5.  A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage.

Authors:  Jannik N Andersen; Peter G Jansen; Søren M Echwald; Ole H Mortensen; Toshiyuki Fukada; Robert Del Vecchio; Nicholas K Tonks; Niels Peter H Møller
Journal:  FASEB J       Date:  2004-01       Impact factor: 5.191

Review 6.  Protein tyrosine phosphatases in the human genome.

Authors:  Andres Alonso; Joanna Sasin; Nunzio Bottini; Ilan Friedberg; Iddo Friedberg; Andrei Osterman; Adam Godzik; Tony Hunter; Jack Dixon; Tomas Mustelin
Journal:  Cell       Date:  2004-06-11       Impact factor: 41.582

7.  Mutational analysis of the tyrosine phosphatome in colorectal cancers.

Authors:  Zhenghe Wang; Dong Shen; D Williams Parsons; Alberto Bardelli; Jason Sager; Steve Szabo; Janine Ptak; Natalie Silliman; Brock A Peters; Michiel S van der Heijden; Giovanni Parmigiani; Hai Yan; Tian-Li Wang; Greg Riggins; Steven M Powell; James K V Willson; Sanford Markowitz; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu
Journal:  Science       Date:  2004-05-21       Impact factor: 47.728

8.  Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression.

Authors:  Kalpana Ghoshal; Sarmila Majumder; Jharna Datta; Tasneem Motiwala; Shoumei Bai; Sudarshana M Sharma; Wendy Frankel; Samson T Jacob
Journal:  J Biol Chem       Date:  2003-11-10       Impact factor: 5.157

Review 9.  The rise and fall of genomic methylation in cancer.

Authors:  Assam El-Osta
Journal:  Leukemia       Date:  2004-02       Impact factor: 11.528

10.  Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer.

Authors:  Tasneem Motiwala; Huban Kutay; Kalpana Ghoshal; Shoumei Bai; Hiroyuki Seimiya; Takashi Tsuruo; Saul Suster; Carl Morrison; Samson T Jacob
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-08       Impact factor: 11.205
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  31 in total

1.  Influence of 6q22-23 on overall survival in primary central nervous system lymphoma. Analysis of North Central Cancer Treatment Group trials 86 72 52, 93 73 51 and 96 73 51.

Authors:  Ellen R McPhail; Mark E Law; Paul A Decker; Brian P O'Neill
Journal:  Br J Haematol       Date:  2011-01-31       Impact factor: 6.998

Review 2.  Tumour suppressor function of protein tyrosine phosphatase receptor-T.

Authors:  Anthony Scott; Zhenghe Wang
Journal:  Biosci Rep       Date:  2011-10       Impact factor: 3.840

3.  AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia.

Authors:  Tasneem Motiwala; Nicola Zanesi; Jharna Datta; Satavisha Roy; Huban Kutay; Allyn M Checovich; Mohamed Kaou; Yiming Zhong; Amy J Johnson; David M Lucas; Nyla A Heerema; John Hagan; Xiaokui Mo; David Jarjoura; John C Byrd; Carlo M Croce; Samson T Jacob
Journal:  Blood       Date:  2011-10-14       Impact factor: 22.113

Review 4.  Role of protein tyrosine phosphatases in cancer.

Authors:  Tasneem Motiwala; Samson T Jacob
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  2006

5.  SH2 Domain-Containing Phosphatase-2 Is a Novel Antifibrotic Regulator in Pulmonary Fibrosis.

Authors:  Argyrios Tzouvelekis; Guoying Yu; Christian L Lino Cardenas; Jose D Herazo-Maya; Rong Wang; Tony Woolard; Yi Zhang; Koji Sakamoto; Hojin Lee; Jae-Sung Yi; Giuseppe DeIuliis; Nikolaos Xylourgidis; Farida Ahangari; Patty J Lee; Vassilis Aidinis; Erica L Herzog; Robert Homer; Anton M Bennett; Naftali Kaminski
Journal:  Am J Respir Crit Care Med       Date:  2017-02-15       Impact factor: 21.405

6.  Placental DNA methylation alterations associated with maternal tobacco smoking at the RUNX3 gene are also associated with gestational age.

Authors:  Jennifer Z J Maccani; Devin C Koestler; Eugene Andrés Houseman; Carmen J Marsit; Karl T Kelsey
Journal:  Epigenomics       Date:  2013-12       Impact factor: 4.778

7.  PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells.

Authors:  Tasneem Motiwala; Sarmila Majumder; Kalpana Ghoshal; Huban Kutay; Jharna Datta; Satavisha Roy; David M Lucas; Samson T Jacob
Journal:  J Biol Chem       Date:  2008-11-07       Impact factor: 5.157

8.  Methylation of the PTPRO gene in human hepatocellular carcinoma and identification of VCP as its substrate.

Authors:  Shu-hao Hsu; Tasneem Motiwala; Satavisha Roy; Rainer Claus; Mufaddal Mustafa; Christoph Plass; Michael A Freitas; Kalpana Ghoshal; Samson T Jacob
Journal:  J Cell Biochem       Date:  2013-08       Impact factor: 4.429

9.  Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation.

Authors:  Carrie V Breton; Hyang-Min Byun; Made Wenten; Fei Pan; Allen Yang; Frank D Gilliland
Journal:  Am J Respir Crit Care Med       Date:  2009-06-04       Impact factor: 21.405

10.  Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity.

Authors:  Bhuvaneswari Ramaswamy; Sarmila Majumder; Satavisha Roy; Kalpana Ghoshal; Huban Kutay; Jharna Datta; Mamoun Younes; Charles L Shapiro; Tasneem Motiwala; Samson T Jacob
Journal:  Mol Endocrinol       Date:  2008-12-18
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