Literature DB >> 15793163

Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances.

Larry A Bauer1, Douglas J Black, Jennifer S Lill, Julie Garrison, Vidmantas A Raisys, Thomas M Hooton.   

Abstract

Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.

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Year:  2005        PMID： 15793163      PMCID： PMC1068590          DOI： 10.1128/AAC.49.4.1649-1651.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

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Authors:  Wooin Lee; Richard B Kim
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Journal:  J Am Geriatr Soc       Date:  1984-02       Impact factor: 5.562

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Journal:  Clin Pharmacol Ther       Date:  1975-06       Impact factor: 6.875

7.  Trimethoprim inhibition of the renal clearance of procainamide and N-acetylprocainamide.

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8.  Transepithelial transport of levofloxacin in the isolated perfused rat kidney.

Authors:  T Ito; I Yano; Y Hashimoto; K Inui
Journal:  Pharm Res       Date:  2000-02       Impact factor: 4.200

9.  Cimetidine-procainamide pharmacokinetic interaction in man: evidence of competition for tubular secretion of basic drugs.

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Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

10.  Trimethoprim alters the disposition of procainamide and N-acetylprocainamide.

Authors:  T Kosoglou; M L Rocci; P H Vlasses
Journal:  Clin Pharmacol Ther       Date:  1988-10       Impact factor: 6.875
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Review 4.  Effects of drug transporters on volume of distribution.

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7.  Pharmacokinetic drug interactions of antimicrobial drugs: a systematic review on oxazolidinones, rifamycines, macrolides, fluoroquinolones, and Beta-lactams.

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