Literature DB >> 15792724

Characterization of an N-acylated glucagon-like peptide-1 derivative by electron capture dissociation.

Kim F Haselmann1, Per F Nielsen, Roman A Zubarev.   

Abstract

An N-acylated glucagon-like peptide 1 derivative was characterized by Fourier transform ion cyclotron resonance mass spectrometry. Both electron capture dissociation (ECD) and sustained off-resonance irradiation collisionally activated dissociation (SORI-CAD) were employed. While ECD revealed full sequence coverage, site of modification, branching point, structure of the palmitoylated modification, SORI-CAD produced less complete and more ambiguous information attributable to facile losses of the fatty acid group from both parent and fragments. Thus, ECD showed a superior characterization performance over SORI-CAD in analysis of N-acylated polypeptides.

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Year:  2005        PMID： 15792724     DOI： 10.1016/j.jasms.2005.01.009

Source DB:  PubMed          Journal:  J Am Soc Mass Spectrom        ISSN： 1044-0305            Impact factor:   3.109


  23 in total

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Authors:  J V Olsen; K F Haselmann; M L Nielsen; B A Budnik; P E Nielsen; R A Zubarev
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2.  Tandem mass spectrometry of large biomolecule ions by blackbody infrared radiative dissociation.

Authors:  W D Price; P D Schnier; E R Williams
Journal:  Anal Chem       Date:  1996-03-01       Impact factor: 6.986

3.  Localization of O-glycosylation sites in peptides by electron capture dissociation in a Fourier transform mass spectrometer.

Authors:  E Mirgorodskaya; P Roepstorff; R A Zubarev
Journal:  Anal Chem       Date:  1999-10-15       Impact factor: 6.986

Review 4.  Is glucagon-like peptide 1 an incretin hormone?

Authors:  M A Nauck
Journal:  Diabetologia       Date:  1999-03       Impact factor: 10.122

5.  Electron capture dissociation and infrared multiphoton dissociation MS/MS of an N-glycosylated tryptic peptic to yield complementary sequence information.

Authors:  K Håkansson; H J Cooper; M R Emmett; C E Costello; A G Marshall; C L Nilsson
Journal:  Anal Chem       Date:  2001-09-15       Impact factor: 6.986

6.  Mass spectrometric analysis of recombinant adenylate cyclase toxin from Bordetella pertussis strain 18323/pHSP9.

Authors:  V Havlícek; L Higgins; W Chen; P Halada; P Sebo; H Sakamoto; M Hackett
Journal:  J Mass Spectrom       Date:  2001-04       Impact factor: 1.982

7.  Why Are B ions stable species in peptide spectra?

Authors:  T Yalcin; C Khouw; I G Csizmadia; M R Peterson; A G Harrison
Journal:  J Am Soc Mass Spectrom       Date:  1995-12       Impact factor: 3.109

8.  Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man.

Authors:  A Wettergren; B Schjoldager; P E Mortensen; J Myhre; J Christiansen; J J Holst
Journal:  Dig Dis Sci       Date:  1993-04       Impact factor: 3.199

9.  Secondary losses via gamma-lactam formation in hot electron capture dissociation: a missing link to complete de novo sequencing of proteins?

Authors:  Frank Kjeldsen; Roman Zubarev
Journal:  J Am Chem Soc       Date:  2003-06-04       Impact factor: 15.419

10.  Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo.

Authors:  C F Deacon; A H Johnsen; J J Holst
Journal:  J Clin Endocrinol Metab       Date:  1995-03       Impact factor: 5.958
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  2 in total

1.  Electron capture dissociation and collision induced dissociation of S-dipalmitoylated peptides.

Authors:  Małgorzata A Kaczorowska; Helen J Cooper
Journal:  J Am Soc Mass Spectrom       Date:  2013-06-01       Impact factor: 3.109

2.  Characterization of 4-hydroxy-2-nonenal-modified peptides by liquid chromatography-tandem mass spectrometry using data-dependent acquisition: neutral loss-driven MS3 versus neutral loss-driven electron capture dissociation.

Authors:  Navin Rauniyar; Stanley M Stevens; Katalin Prokai-Tatrai; Laszlo Prokai
Journal:  Anal Chem       Date:  2009-01-15       Impact factor: 6.986
  2 in total

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