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Literature DB >> 15790958

Homeobox protein Hop functions in the adult cardiac conduction system.

Fraz A Ismat¹, Maozhen Zhang, Hyun Kook, Bin Huang, Rong Zhou, Victor A Ferrari, Jonathan A Epstein, Vickas V Patel.

Abstract

Hop is an unusual homeobox gene expressed in the embryonic and adult heart. Hop acts downstream of Nkx2-5 during development, and Nkx2-5 mutations are associated with cardiac conduction system (CCS) defects. Inactivation of Hop in the mouse is lethal in half of the expected null embryos. Here, we show that Hop is expressed strongly in the adult CCS. Hop-/- adult mice display conduction defects below the atrioventricular node (AVN) as determined by invasive electrophysiological testing. These defects are associated with decreased expression of connexin40. Our results suggest that Hop functions in the adult CCS and demonstrate conservation of molecular hierarchies between embryonic myocardium and the specialized conduction tissue of the mature heart.

Entities: Disease Gene Species

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Year: 2005 PMID： 15790958 PMCID： PMC1615918 DOI： 10.1161/01.RES.0000163108.47258.f3

Source DB: PubMed Journal: Circ Res ISSN： 0009-7330 Impact factor: 17.367

19 in total

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Authors: R G Gourdie; Y Wei; D Kim; S C Klatt; T Mikawa
Journal: Proc Natl Acad Sci U S A Date: 1998-06-09 Impact factor: 11.205

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Journal: J Pharmacol Toxicol Methods Date: 1993-12 Impact factor: 1.950

5. Modulation of cardiac growth and development by HOP, an unusual homeodomain protein.

Authors: Chong Hyun Shin; Zhi-Ping Liu; Robert Passier; Chun-Li Zhang; Da-Zhi Wang; Thomas M Harris; Hiroyuki Yamagishi; James A Richardson; Geoffrey Childs; Eric N Olson
Journal: Cell Date: 2002-09-20 Impact factor: 41.582

6. Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop.

Authors: Hyun Kook; John J Lepore; Aaron D Gitler; Min Min Lu; Wendy Wing-Man Yung; Joel Mackay; Rong Zhou; Victor Ferrari; Peter Gruber; Jonathan A Epstein
Journal: J Clin Invest Date: 2003-09 Impact factor: 14.808

7. Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system.

Authors: Patrick Y Jay; Brett S Harris; Colin T Maguire; Antje Buerger; Hiroko Wakimoto; Makoto Tanaka; Sabina Kupershmidt; Dan M Roden; Thomas M Schultheiss; Terrence X O'Brien; Robert G Gourdie; Charles I Berul; Seigo Izumo
Journal: J Clin Invest Date: 2004-04 Impact factor: 14.808

8. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block.

Authors: Mohammad Pashmforoush; Jonathan T Lu; Hanying Chen; Tara St Amand; Richard Kondo; Sylvain Pradervand; Sylvia M Evans; Bob Clark; James R Feramisco; Wayne Giles; Siew Yen Ho; D Woodrow Benson; Michael Silberbach; Weinian Shou; Kenneth R Chien
Journal: Cell Date: 2004-04-30 Impact factor: 41.582

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Authors: Rong Zhou; Stephen Pickup; Jerry D Glickson; Craig H Scott; Victor A Ferrari
Journal: Magn Reson Med Date: 2003-04 Impact factor: 4.668

29 in total

1. Characterization of sinoatrial node in four conduction system marker mice.

Authors: S Viswanathan; J B E Burch; G I Fishman; I P Moskowitz; D W Benson
Journal: J Mol Cell Cardiol Date: 2007-02-22 Impact factor: 5.000

2. Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.

Authors: Willem M H Hoogaars; Angela Engel; Janynke F Brons; Arie O Verkerk; Frederik J de Lange; L Y Elaine Wong; Martijn L Bakker; Danielle E Clout; Vincent Wakker; Phil Barnett; Jan Hindrik Ravesloot; Antoon F M Moorman; E Etienne Verheijck; Vincent M Christoffels
Journal: Genes Dev Date: 2007-05-01 Impact factor: 11.361

3. Class I Histone Deacetylase Inhibition for the Treatment of Sustained Atrial Fibrillation.

Authors: Mitsuru Seki; Ryan LaCanna; Jeffery C Powers; Christine Vrakas; Fang Liu; Remus Berretta; Geena Chacko; John Holten; Pooja Jadiya; Tao Wang; Jeffery S Arkles; Joshua M Copper; Steven R Houser; Jianhe Huang; Vickas V Patel; Fabio A Recchia
Journal: J Pharmacol Exp Ther Date: 2016-06-27 Impact factor: 4.030

Homeobox protein Hop functions in the adult cardiac conduction system.

1. Endothelin-induced conversion of embryonic heart muscle cells into impulse-conducting Purkinje fibers.

2. In vivo cardiac electrophysiology studies in the mouse.

3. Histochemical methods for separate, consecutive and simultaneous demonstration of acetylcholinesterase and norepinephrine in cryostat sections.

4. Use of telemetry to record electrocardiogram and heart rate in freely moving mice.

5. Modulation of cardiac growth and development by HOP, an unusual homeodomain protein.

6. Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop.

7. Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system.

8. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block.

9. Congenital heart disease caused by mutations in the transcription factor NKX2-5.

10. Assessment of global and regional myocardial function in the mouse using cine and tagged MRI.

1. Characterization of sinoatrial node in four conduction system marker mice.

2. Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.

3. Class I Histone Deacetylase Inhibition for the Treatment of Sustained Atrial Fibrillation.

Review 4. Gene regulatory networks in cardiac conduction system development.

Review 5. Role of homeodomain-only protein in the cardiac conduction system.

Review 6. Fates Aligned: Origins and Mechanisms of Ventricular Conduction System and Ventricular Wall Development.

7. Contactin-2 expression in the cardiac Purkinje fiber network.

8. Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways.

9. N-cadherin haploinsufficiency affects cardiac gap junctions and arrhythmic susceptibility.

10. Setting the pace: Tbx3 and Tbx18 in cardiac conduction system development.