Literature DB >> 15789746

Butyrylcholinesterase inhibitory guaianolides from Amberboa ramosa.

Sher Bahadar Khan1, Shagufta Perveen, Nighat Afza, Abdul Malik, Sarfraz Ahmad Nawaz, Muhammad Raza Shah, Muhammad Iqbal Choudhary.   

Abstract

Phytochemical investigation of the whole plant of Amberboa ramosa led to the isolation of six sesquiterpene lactones which could be identified as 8alpha-hydroxy-11beta-methyl-1alphaH, 5alphaH, 6betaH, 7alphaH, 11alphaH-guai-10(14), 4(15)-dien-6, 12-olide(1), 3beta, 8alpha-dihydroxy-11alpha-methyl-1alphaH, 5alphaH, 6betaH, 7alphaH, 11betaH-guai-10(14), 4 (15)-dien-6, 12-olide (2), 3beta, 4alpha, 8alpha-trihydroxy-4beta-(hydroxymethyl)-1alphaH, 5alphaH, 6betaH, 7alphaH-guai-10(14), 11(13)-dien-6, 12-olide (3), 3beta, 4alpha, 8alpha-trihydroxy-4beta-(chloromethyl)-1alphaH, 5alphaH, 6betaH, 7alphaH-guai-10(14),11(13)-dien-6, 12-olide(4), 3beta, 4alpha, dihydroxy-4beta-(hydroxymethyl)-1alphaH, 5alphaH, 6betaH, 7alphaH-guai-10(14),11(13)-dien-6, 12-olide(5), 3beta, 4alpha-dihydroxy-4beta-(chloromethyl)-8alpha-(4-hydroxymethacrylate)-1alphaH, 5alphaH, 6betaH, 7alphaH-guai-10(14),11 (13)-dien-6,12-olide (6) by spectroscopic methods. All of them showed inhibitory potential against butyrylcholinesterase.

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Year:  2005        PMID： 15789746     DOI： 10.1007/BF02977710

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  5 in total

1.  Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents.

Authors:  Brian C Geyer; Latha Kannan; Pierre-Emmanuel Garnaud; Clarence A Broomfield; C Linn Cadieux; Irene Cherni; Sean M Hodgins; Shane A Kasten; Karli Kelley; Jacquelyn Kilbourne; Zeke P Oliver; Tamara C Otto; Ian Puffenberger; Tony E Reeves; Neil Robbins; Ryan R Woods; Hermona Soreq; David E Lenz; Douglas M Cerasoli; Tsafrir S Mor
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-08       Impact factor: 11.205

2.  Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity.

Authors:  Katherine E Larrimore; Matthew Barcus; Latha Kannan; Yang Gao; Chang-Guo Zhan; Stephen Brimijoin; Tsafrir Mor
Journal:  Chem Biol Interact       Date:  2012-09-20       Impact factor: 5.192

3.  5,7-Dihy-droxy-3,6-dimeth-oxy-2-(4-meth-oxy-phen-yl)-4H-chromen-4-one monohydrate.

Authors:  Akhtar Mohammad; Itrat Anis; Vickie McKee; Josef W A Frese; Muhammad Raza Shah
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-10-02

4.  Acetyl and butyryl cholinesterase inhibitory sesquiterpene lactones from Amberboa ramosa.

Authors:  Muhammad Ibrahim; Tahir Farooq; Nusrat Hussain; Amjad Hussain; Tahsin Gulzar; Iqbal Hussain; Muhammad Sajid Akash; Fouzia Sultana Rehmani
Journal:  Chem Cent J       Date:  2013-07-10       Impact factor: 4.215

5.  Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity.

Authors:  Katherine E Larrimore; I Can Kazan; Latha Kannan; R Player Kendle; Tameem Jamal; Matthew Barcus; Ashini Bolia; Stephen Brimijoin; Chang-Guo Zhan; S Banu Ozkan; Tsafrir S Mor
Journal:  Sci Rep       Date:  2017-09-05       Impact factor: 4.379
  5 in total

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