PURPOSE: To evaluate the neuroprotective efficacy of brimonidine applied topically to the eyes of patients undergoing laser treatment for extrafoveal or juxtafoveal choroidal neovascularization (CNV). METHOD: In this prospective, controlled, double-masked pilot study, 20 eyes were randomized to receive either brimonidine 0.2% (study group, 11 eyes) or placebo (matched control group, 9 eyes). Medications were topically applied twice a day during a period of 4-48 h before laser treatment and were continued for 1 month. RESULTS: Two eyes in each group had severe visual loss owing to recurrence of CNV. In the remaining 16 eyes there was a significant improvement in the study group, but no improvement in the control group (P=0.027). CONCLUSION:Topical brimonidine improves the visual outcome of laser-treated classic extrafoveal or juxtafoveal CNV, possibly by protecting the neuroretina against collateral damage caused by the laser treatment.
RCT Entities:
PURPOSE: To evaluate the neuroprotective efficacy of brimonidine applied topically to the eyes of patients undergoing laser treatment for extrafoveal or juxtafoveal choroidal neovascularization (CNV). METHOD: In this prospective, controlled, double-masked pilot study, 20 eyes were randomized to receive either brimonidine 0.2% (study group, 11 eyes) or placebo (matched control group, 9 eyes). Medications were topically applied twice a day during a period of 4-48 h before laser treatment and were continued for 1 month. RESULTS: Two eyes in each group had severe visual loss owing to recurrence of CNV. In the remaining 16 eyes there was a significant improvement in the study group, but no improvement in the control group (P=0.027). CONCLUSION: Topical brimonidine improves the visual outcome of laser-treated classic extrafoveal or juxtafoveal CNV, possibly by protecting the neuroretina against collateral damage caused by the laser treatment.
Authors: H Levkovitch-Verbin; C Harris-Cerruti; Y Groner; L A Wheeler; M Schwartz; E Yoles Journal: Invest Ophthalmol Vis Sci Date: 2000-12 Impact factor: 4.799
Authors: Shereen Nizari; Li Guo; Benjamin M Davis; Eduardo M Normando; Joana Galvao; Lisa A Turner; Mukhtar Bizrah; Mohammad Dehabadi; Kailin Tian; M Francesca Cordeiro Journal: Cell Death Dis Date: 2016-12-08 Impact factor: 8.469