Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Cardiotoxic effects of astemizole overdose in children.

Literature DB >> 1578320

Cardiotoxic effects of astemizole overdose in children.

J F Wiley¹, M L Gelber, F M Henretig, C C Wiley, S Sandhu, J Loiselle.

Abstract

Astemizole, a nonsedating antihistamine, caused a prolonged corrected QT interval, ventricular dysrhythmias, and atrioventricular heart block after overdose in five children. Cardiotoxic effects lasted an average of 2 1/2 days. Children poisoned with astemizole need emergent medical evaluation, a 12-lead electrocardiogram with calculation of the corrected QT interval, and continuous cardiac monitoring for 24 hours.

Entities: Chemical Disease Species

Mesh：

Substances：
Astemizole

Year: 1992 PMID： 1578320 DOI： 10.1016/s0022-3476(05)80252-5

Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406

Keyword Cloud
Cited

12 in total

1. Computer-based analysis of dynamic QT changes: toward high precision and individual rate correction.

Authors: Corina Dota; Bo Skallefell; Nils Edvardsson; Gunnar Fager
Journal: Ann Noninvasive Electrocardiol Date: 2002-10 Impact factor: 1.468

Review 2. Cytochrome P450 3A: ontogeny and drug disposition.

Authors: S N de Wildt; G L Kearns; J S Leeder; J N van den Anker
Journal: Clin Pharmacokinet Date: 1999-12 Impact factor: 6.447

Review 3. Comparative tolerability of second generation antihistamines.

Authors: F Horak; U P Stübner
Journal: Drug Saf Date: 1999-05 Impact factor: 5.606

4. Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.

Authors: Hanna Phan; Matthew L Moeller; Milap C Nahata
Journal: Drugs Date: 2009 Impact factor: 9.546

5. Public health problems and the rapid estimation of the size of the population at risk. Torsades de pointes and the use of terfenadine and astemizole in The Netherlands.

Authors: R M Herings; B H Stricker; H G Leufkens; A Bakker; F Sturmans; J Urquhart
Journal: Pharm World Sci Date: 1993-10-15

Cardiotoxic effects of astemizole overdose in children.

1. Computer-based analysis of dynamic QT changes: toward high precision and individual rate correction.

Review 2. Cytochrome P450 3A: ontogeny and drug disposition.

Review 3. Comparative tolerability of second generation antihistamines.

4. Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.

5. Public health problems and the rapid estimation of the size of the population at risk. Torsades de pointes and the use of terfenadine and astemizole in The Netherlands.

Review 6. Macrolide antibacterials. Drug interactions of clinical significance.

7. Possible interactions with terfenadine or astemizole.

Review 8. H1-receptor antagonists. Comparative tolerability and safety.

Review 9. Safety and tolerability of treatments for allergic rhinitis in children.

10. Design of a Precision Medication Dispenser: Preventing Overdose by Increasing Accuracy and Precision of Dosage.