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Literature DB >> 15783176

(SR/RS)-cyclohexanyl PNAs: conformationally preorganized PNA analogues with unprecedented preference for duplex formation with RNA.

T Govindaraju¹, Vaijayanti A Kumar, Krishna N Ganesh.

Abstract

PNA oligomers H-GTAGATCAT-lys-NH2 with cis-(1S,2R/1R,2S)-cyclohexyl-T (III) in the backbone form PNA:RNA duplexes with Tm approximately 30-50 degrees C higher than that of PNA:DNA duplexes. In comparison, cis-(1S,2R/1R,2S)-cyclopentyl PNA-T (IV) form highly stable duplexes with both RNA and DNA without discrimination.

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Year: 2005 PMID： 15783176 DOI： 10.1021/ja044142v

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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Cited

8 in total

Review 1. Insights on chiral, backbone modified peptide nucleic acids: Properties and biological activity.

Authors: Maria Moccia; Mauro F A Adamo; Michele Saviano
Journal: Artif DNA PNA XNA Date: 2016-01-11

2. Pyrrolidinyl peptide nucleic acid with α/β-peptide backbone: A conformationally constrained PNA with unusual hybridization properties.

Authors: Chotima Vilaivan; Choladda Srisuwannaket; Cheeraporn Ananthanawat; Chaturong Suparpprom; Junji Kawakami; Yoshie Yamaguchi; Yuko Tanaka; Tirayut Vilaivan
Journal: Artif DNA PNA XNA Date: 2011-04

Review 3. Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications.

Authors: Chaturong Suparpprom; Tirayut Vilaivan
Journal: RSC Chem Biol Date: 2022-03-18

4. Impact of bPNA Backbone Structural Constraints and Composition on Triplex Hybridization with DNA.

Authors: Oliver Munyaradzi; Sarah Rundell; Dennis Bong
Journal: Chembiochem Date: 2022-02-26 Impact factor: 3.461

5. (α,α-dimethyl)glycyl (dmg) PNAs: achiral PNA analogs that form stronger hybrids with cDNA relative to isosequential RNA.

Authors: Aland Gourishankar; Krishna N Ganesh
Journal: Artif DNA PNA XNA Date: 2012 Jan-Mar

(SR/RS)-cyclohexanyl PNAs: conformationally preorganized PNA analogues with unprecedented preference for duplex formation with RNA.

Review 1. Insights on chiral, backbone modified peptide nucleic acids: Properties and biological activity.

2. Pyrrolidinyl peptide nucleic acid with α/β-peptide backbone: A conformationally constrained PNA with unusual hybridization properties.

Review 3. Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications.

4. Impact of bPNA Backbone Structural Constraints and Composition on Triplex Hybridization with DNA.

5. (α,α-dimethyl)glycyl (dmg) PNAs: achiral PNA analogs that form stronger hybrids with cDNA relative to isosequential RNA.

6. Enhanced Triplex Hybridization of DNA and RNA via Syndiotactic Side Chain Presentation in Minimal bPNAs.

Review 7. Chiral peptide nucleic acids with a substituent in the N-(2-aminoethy)glycine backbone.

Review 8. Antibacterial Peptide Nucleic Acids-Facts and Perspectives.