Literature DB >> 15782558

Microphthalmia transcription factor: a specific marker for malignant melanoma.

J Vachtenheim1, J Borovanský.   

Abstract

The transcription factor microphthalmia (MITF) is required for the formation of normal melanocytes during embryonic development and for the expression of pigment cell-specific markers, which are the downstream transcriptional targets of MITF. It also seems to be crucial for the survival of malignant melanocytes. The special interest of this review is the possible utility of MITF as a marker of malignant melanoma. Melanocyte-specific isoform of MITF appears to be a unique molecule in the differential diagnosis of melanocytic tumors.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15782558

Source DB:  PubMed          Journal:  Prague Med Rep        ISSN： 1214-6994


  5 in total

1.  Specific targeting of Wnt/β-catenin signaling in human melanoma cells by a dietary triterpene lupeol.

Authors:  Rohinton S Tarapore; Imtiaz A Siddiqui; Mohammad Saleem; Vaqar M Adhami; Vladimir S Spiegelman; Hasan Mukhtar
Journal:  Carcinogenesis       Date:  2010-08-23       Impact factor: 4.944

2.  Mitf-Mdel, a novel melanocyte/melanoma-specific isoform of microphthalmia-associated transcription factor-M, as a candidate biomarker for melanoma.

Authors:  Yixiang Wang; Soroosh Radfar; Suhu Liu; Adam I Riker; Hung T Khong
Journal:  BMC Med       Date:  2010-02-17       Impact factor: 8.775

3.  Microphthalmia transcription factor as a molecular marker for circulating tumor cell detection in blood of melanoma patients.

Authors:  Kazuo Koyanagi; Steven J O'Day; Rene Gonzalez; Karl Lewis; William A Robinson; Thomas T Amatruda; Christine Kuo; He-Jing Wang; Robert Milford; Donald L Morton; Dave S B Hoon
Journal:  Clin Cancer Res       Date:  2006-02-15       Impact factor: 12.531

4.  Micropthalmia transcription factor (MITF) as a diagnostic marker for metastatic melanomas negative for other melanoma markers.

Authors:  Ruifeng Guo; Maria Franco-Palacios; Madison Russell; Lindsey Goddard; Lewis Hassell; Elizabeth Gillies; Kar-Ming Fung
Journal:  Int J Clin Exp Pathol       Date:  2013-07-15

5.  MiTF regulates cellular response to reactive oxygen species through transcriptional regulation of APE-1/Ref-1.

Authors:  Feng Liu; Yan Fu; Frank L Meyskens
Journal:  J Invest Dermatol       Date:  2008-10-30       Impact factor: 8.551
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.