| Literature DB >> 15781390 |
Grigoris Zoidis1, Ioannis Papanastasiou, Ioannis Dotsikas, Alejandro Sandoval, Raquel Gouvea Dos Santos, Zeta Papadopoulou-Daifoti, Alexander Vamvakides, Nicolas Kolocouris, Ricardo Felix.
Abstract
A facile preparation of 2-aminomethyl-2-tricyclo[3.3.1.1(1,7)]decaneacetic acid hydrochloride 5 (AdGABA) is described. The synthesis of AdGABA involves the hydrogenation of 2-cyano-2-tricyclo[3.3.1.1(1,7)]decaneacetic acid 11, which was synthesized by two different synthetic routes. AdGABA was found to antagonize the pentylenetetrazole (PTZ) and semicarbazide (SCZ) induced tonic convulsions and exhibits analgesic activity in the hot plate test on mice. Although its mechanism of action is quite similar to that proposed previously for gabapentin (interaction with the alpha2delta subunit of the voltage gated Ca2+ channels), further studies were undertaken in order to clarify the precise mechanism of the anticonvulsant and analgesic effects of AdGABA on a molecular level.Entities:
Mesh：
Substances：
Year: 2005 PMID： 15781390 DOI： 10.1016/j.bmc.2005.02.030
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641