Literature DB >> 15780622

Synthesis and anticonvulsant activity of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles.

Afshin Zarghi1, Sayyed A Tabatabai, Mehrdad Faizi, Avideh Ahadian, Parisa Navabi, Vahideh Zanganeh, Abbas Shafiee.   

Abstract

A series of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles have been synthesized and evaluated as anticonvulsant agents. Compound 4b shows considerable anticonvulsant activity both in PTZ and MES models. It seems this effect is mediated through benzodiazepine receptors mechanism.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15780622     DOI： 10.1016/j.bmcl.2005.02.014

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  23 in total

1.  Synthesis of a series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives as potential antioxidant and antibacterial agents.

Authors:  M Aruna Sindhe; Yadav D Bodke; R Kenchappa; Sandeep Telkar; A Chandrashekar
Journal:  J Chem Biol       Date:  2016-07-07

2.  Synthesis and Biological Evaluation of beta-Aroylpropionic acid based 1,3,4-Oxadiazoles.

Authors:  A Husain; Priyanka Ahuja
Journal:  Indian J Pharm Sci       Date:  2009-01       Impact factor: 0.975

3.  Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by a new series of substituted-1,3,4-oxadiazole derivatives.

Authors:  Akhilesh Kumar; Saritha S D'Souza; S L Gaonkar; K M L Rai; Bharathi P Salimath
Journal:  Invest New Drugs       Date:  2008-01-29       Impact factor: 3.850

4.  Design, synthesis, and preliminary pharmacological evaluation of novel thiazolidinone derivatives as potential benzodiazepine agonists.

Authors:  Ali Almasirad; Maryam Ghadimi; Saeideh Mirahmadi; Pouya Ahmadian Kodakan; Reza Jahani; Maryam Nazari; Elham Rezaee; Homa Azizian; Parmida Rabizadeh; Sayyed Abbas Tabatabai; Mehrdad Faizi
Journal:  Mol Divers       Date:  2021-01-23       Impact factor: 2.943

5.  Synthesis and Antioxidant Activity of 2-Amino-5-methylthiazol Derivatives Containing 1,3,4-Oxadiazole-2-thiol Moiety.

Authors:  Kikkeri N Mohana; Chikkur B Pradeep Kumar
Journal:  ISRN Org Chem       Date:  2013-08-19

6.  Synthesis and antimicrobial activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones.

Authors:  Navin B Patel; Jaymin C Patel
Journal:  Sci Pharm       Date:  2010-04-26

7.  (S)-N-[1-(5-Benzyl-sulfan-yl-1,3,4-oxa-diazol-2-yl)-2-phenyl-eth-yl]-4-methyl-benzene-sulfonamide.

Authors:  Tayyaba Syed; Shahid Hameed; Peter G Jones
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-10-08

8.  Evaluation of Anxiolytic, Sedative-hypnotic and Amnesic Effects of Novel 2-phenoxy phenyl-1,3,4-oxadizole Derivatives Using Experimental Models.

Authors:  Sayyed Abbas Tabatabai; Elham Rezaee Zavareh; Hamed Reyhanfard; Bagher Alinezhad; Bijan Shafaghi; Majid Sheikhha; Abbas Shafiee; Mehrdad Faizi
Journal:  Iran J Pharm Res       Date:  2015       Impact factor: 1.696

9.  Design, Synthesis and Pharmacological Evaluation of Novel 2-[2-(2-Chlorophenoxy) phenyl]-1,3,4-oxadiazole Derivatives as Benzodiazepine Receptor Agonists.

Authors:  Mehrdad Faizi; Majid Sheikhha; Nematollah Ahangar; Hamed Tabatabaei Ghomi; Bijan Shafaghi; Abbas Shafiee; Seyyed Abbas Tabatabai
Journal:  Iran J Pharm Res       Date:  2012       Impact factor: 1.696

10.  Synthesis and evaluation of antiinflammatory, analgesic and ulcerogenic potential of NSAIDs bearing 1,3,4-oxadiazole scaffold.

Authors:  R R Somani; U V Bhanushali
Journal:  Indian J Pharm Sci       Date:  2011-11       Impact factor: 0.975
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.