Literature DB >> 15777701

Biochemical manifestations of anti-tuberculosis drugs induced hepatotoxicity and the effect of silymarin.

Sheikh A Tasduq1, Kaiser Peerzada, Supriya Koul, Rinku Bhat, Rakesh K Johri.   

Abstract

In the present study, the biochemical manifestations of liver toxicity caused by co-administration of anti-TB drugs, rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA), in a sub-chronic mode (12 weeks), were investigated. Significant alterations were revealed in (a) increased levels of alanine aminotrasferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) and a high bilirubin content in serum; (b) elevated lipid peroxidation (LPO), intracellular calcium [Ca(2+)](i) and CYP4502EI activity in liver; and (c) decreased glutathione (GSH) content, glutathione peroxidase (GPx) and catalase activities in liver. Silymarin reversed these abnormal alterations. The biochemical changes were supported by histological observations.

Entities:  

Year:  2005        PMID： 15777701     DOI： 10.1016/j.hepres.2005.01.005

Source DB:  PubMed          Journal:  Hepatol Res        ISSN： 1386-6346            Impact factor:   4.288


  22 in total

1.  Ameliorating role of caffeic acid phenethyl ester (CAPE) against isoniazid-induced oxidative damage in red blood cells.

Authors:  Osman Gokalp; Efkan Uz; Ekrem Cicek; H Ramazan Yilmaz; Mehmet Kaya Ozer; Ayse Altunbas; Nurten Ozcelik
Journal:  Mol Cell Biochem       Date:  2006-09-09       Impact factor: 3.396

Review 2.  Hepatotoxic effects of therapies for tuberculosis.

Authors:  Bahaa E Senousy; Sanaa I Belal; Peter V Draganov
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2010-08-31       Impact factor: 46.802

3.  Effect of garlic on isoniazid and rifampicin-induced hepatic injury in rats.

Authors:  Ravinder Pal; Kim Vaiphei; Arbab Sikander; Kartar Singh; Satya V Rana
Journal:  World J Gastroenterol       Date:  2006-01-28       Impact factor: 5.742

Review 4.  Antitubercular therapy in patients with cirrhosis: challenges and options.

Authors:  Naveen Kumar; Chandan Kumar Kedarisetty; Sachin Kumar; Vikas Khillan; Shiv Kumar Sarin
Journal:  World J Gastroenterol       Date:  2014-05-21       Impact factor: 5.742

5.  Assessing the risk of birth defects associated with exposure to fixed-dose combined antituberculous agents during pregnancy in rats.

Authors:  O Awodele; E B Patrick; Esther Oluwatoyin Agbaje; A A Oremosu; S C Gbotolorun
Journal:  ScientificWorldJournal       Date:  2012-05-03

6.  Damage of testicular cell macromolecules and reproductive capacity of male rats following co-administration of ethambutol, rifampicin, isoniazid and pyrazinamide.

Authors:  Ganna Mykhailivna Shayakhmetova; Larysa Borysivna Bondarenko; Valentina Mykolaivna Kovalenko
Journal:  Interdiscip Toxicol       Date:  2012-03

7.  Hepatoprotective activity of melittin on isoniazid- and rifampicin-induced liver injuries in male albino rats.

Authors:  Khalid Mohammed Naji; Bushra Yahya Al-Khatib; Nora Saif Al-Haj; Myrene R D'souza
Journal:  BMC Pharmacol Toxicol       Date:  2021-07-03       Impact factor: 2.483

8.  Effectiveness of ellagic acid on isoniazid-rifampicin induced liver damage in rats.

Authors:  Samuel Stephen Ambrose; Ponnu Solairaj; Appian Subramoniam
Journal:  J Pharmacol Pharmacother       Date:  2013-01

9.  Hepatoprotective Effect of Cissus quadrangularis Stem Extract Against Rifampicin-induced Hepatotoxicity in Rats.

Authors:  A H M Viswanatha Swamy; Rucha V Kulkarni; B C Koti; P C Gadad; A H M Thippeswamy; Aparna Gore
Journal:  Indian J Pharm Sci       Date:  2012-03       Impact factor: 0.975

10.  Silymarin protects liver against toxic effects of anti-tuberculosis drugs in experimental animals.

Authors:  Sude Eminzade; Fikriye Uraz; Fikret V Izzettin
Journal:  Nutr Metab (Lond)       Date:  2008-07-05       Impact factor: 4.169
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