Literature DB >> 15774900

Transcriptional analysis of the principal cell division gene, ftsZ, of Mycobacterium tuberculosis.

Sougata Roy1, Parthasarathi Ajitkumar.   

Abstract

Multiple promoters drive the expression of the principal cell division gene, ftsZ, in bacterial systems. Primer extension analysis of total RNA from Mycobacterium tuberculosis and a Mycobacterium smegmatis transformant containing 1.117 kb of the upstream region of M. tuberculosis ftsZ and promoter fusion studies identified six ftsZ transcripts and their promoters in the ftsQ open reading frame and ftsQ-ftsZ intergenic region. The presence of multiple promoters reflects the requirement to maintain a high basal level of, or to differentially regulate, FtsZ expression during different growth conditions of the pathogen in vivo.

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Year:  2005        PMID: 15774900      PMCID: PMC1065227          DOI: 10.1128/JB.187.7.2540-2550.2005

Source DB:  PubMed          Journal:  J Bacteriol        ISSN: 0021-9193            Impact factor:   3.490


  44 in total

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Authors:  E F Bi; J Lutkenhaus
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7.  Highly fluorescent GFPm 2+ -based genome integration-proficient promoter probe vector to study Mycobacterium tuberculosis promoters in infected macrophages.

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8.  Characterisation of ATP-dependent Mur ligases involved in the biogenesis of cell wall peptidoglycan in Mycobacterium tuberculosis.

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  10 in total

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