| Literature DB >> 15774900 |
Sougata Roy1, Parthasarathi Ajitkumar.
Abstract
Multiple promoters drive the expression of the principal cell division gene, ftsZ, in bacterial systems. Primer extension analysis of total RNA from Mycobacterium tuberculosis and a Mycobacterium smegmatis transformant containing 1.117 kb of the upstream region of M. tuberculosis ftsZ and promoter fusion studies identified six ftsZ transcripts and their promoters in the ftsQ open reading frame and ftsQ-ftsZ intergenic region. The presence of multiple promoters reflects the requirement to maintain a high basal level of, or to differentially regulate, FtsZ expression during different growth conditions of the pathogen in vivo.Entities:
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Year: 2005 PMID: 15774900 PMCID: PMC1065227 DOI: 10.1128/JB.187.7.2540-2550.2005
Source DB: PubMed Journal: J Bacteriol ISSN: 0021-9193 Impact factor: 3.490