| Literature DB >> 15773582 |
E Iu Makarenko, L A Andreeva, A S Borovik, A A Mart'ianov.
Abstract
The effects of tripeptide corticoliberin fragment CRF(4-6) (Pro-Pro-Ile) on blood pressure and heart rate of rats were investigated. Intracerebroventricularly injected CRF(4-6) (1.5-15.0 nmol/head) increases the mean arterial pressure and heart rate in conscious and anaesthetized animals in a dose-dependent manner. Corticotropin releasing factor antagonist: alpha-helical CRF(9-41) (6.5 nmol) completely abolished the influence of tripeptide CRF(4-6) (1.5 nmol) on blood pressure and heart rate in anaesthetized rats. This result indicates that corticoliberin receptors are involved in cardiovascular effects of CRF(4-6).Entities:
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Year: 2005 PMID： 15773582
Source DB: PubMed Journal: Ross Fiziol Zh Im I M Sechenova ISSN： 0869-8139