| Literature DB >> 15771489 |
Terra B Potocky1, Anant K Menon, Samuel H Gellman.
Abstract
We have used our ability to control beta-peptide secondary structure in order to explore the effects of conformational stability and geometry of guanidinium display on cell entry. Both of these factors affect the rate and relative amount of beta-peptide accumulation in the cytoplasm and nucleus of live HeLa cells. These beta-peptides do not show significant differences in cell surface binding, implying that structure and guanidinium display are important in a later step in cell entry than initial surface binding.Entities:
Mesh：
Substances：
Year: 2005 PMID： 15771489 DOI： 10.1021/ja042566j
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419