AIM: In the present study, the characteristics of PEI-RFA treatment were further elucidated by analyzing the relationship between the volume of coagulated necrosis and the energy requirement for ablation or the amount of ethanol injected into HCC. METHODS: The volume of coagulated necrosis, total energy requirement and energy requirement for coagulation of per unit volume were examined in the groups of PEI-RFA and RFA alone using the Cool-tip RF system. RESULTS: The results showed that the volume of coagulated necrosis induced was significantly larger in PEI-RFA group than in routine RFA group, when the total energy administered was comparable in both groups. In PEI-RFA, enlargement of coagulated necrosis was admitted in 3 dimensions and the amount of energy requirement per unit volume of coagulated necrosis was negatively correlated with the amount of ethanol injected into HCC. CONCLUSION: These results suggest that, compared to RFA alone, PEI-RFA enables to induce comparable coagulated necrosis with smaller energy requirement, and that PEI-RFA is likely to be less invasive than RFA alone irrespective of inducing enhanced coagulated necrosis. Thus, simple prior injection of ethanol may make RFA treatment more effective and less invasive for the treatment of patients with HCC.
AIM: In the present study, the characteristics of PEI-RFA treatment were further elucidated by analyzing the relationship between the volume of coagulated necrosis and the energy requirement for ablation or the amount of ethanol injected into HCC. METHODS: The volume of coagulated necrosis, total energy requirement and energy requirement for coagulation of per unit volume were examined in the groups of PEI-RFA and RFA alone using the Cool-tip RF system. RESULTS: The results showed that the volume of coagulated necrosis induced was significantly larger in PEI-RFA group than in routine RFA group, when the total energy administered was comparable in both groups. In PEI-RFA, enlargement of coagulated necrosis was admitted in 3 dimensions and the amount of energy requirement per unit volume of coagulated necrosis was negatively correlated with the amount of ethanol injected into HCC. CONCLUSION: These results suggest that, compared to RFA alone, PEI-RFA enables to induce comparable coagulated necrosis with smaller energy requirement, and that PEI-RFA is likely to be less invasive than RFA alone irrespective of inducing enhanced coagulated necrosis. Thus, simple prior injection of ethanol may make RFA treatment more effective and less invasive for the treatment of patients with HCC.
Authors: S Yasuda; H Ito; M Yoshikawa; M Shinozaki; N Goto; H Fujimoto; K Nasu; T Uno; J Itami; K Isobe; N Shigematsu; M Ebara; H Saisho Journal: Int J Oncol Date: 1999-09 Impact factor: 5.650
Authors: L Solbiati; T Ierace; S N Goldberg; S Sironi; T Livraghi; R Fiocca; G Servadio; G Rizzatto; P R Mueller; A Del Maschio; G S Gazelle Journal: Radiology Date: 1997-01 Impact factor: 11.105
Authors: Y Nagata; M Hiraoka; K Akuta; M Abe; M Takahashi; S Jo; Y Nishimura; S Masunaga; M Fukuda; H Imura Journal: Cancer Date: 1990-04-15 Impact factor: 6.860
Authors: Arne Dettmer; Timm-D Kirchhoff; Michael Gebel; Lars Zender; Nisar-P Malek; Bernhard Panning; Ajay Chavan; Herbert Rosenthal; Stefan Kubicka; Susanne Krusche; Sonja Merkesdal; Michael Galanski; Michael-P Manns; Joerg-S Bleck Journal: World J Gastroenterol Date: 2006-06-21 Impact factor: 5.742