Literature DB >> 15770056

Influence of serotonin on the analgesic effect of granisetron on temporomandibular joint arthritis.

Ulle Voog1, Per Alstergren, Edvitar Leibur, Riina Kallikorm, Sigvard Kopp.   

Abstract

The influence of circulating serotonin (5-HT) on the effects of intra-articular administration of granisetron on temporomandibular joint (TMJ) pain was investigated in 11 patients with chronic polyarthritides. An analgesic effect superior to placebo has been shown previously. The change in TMJ movement pain intensity was negatively correlated to circulating 5-HT; that is, the higher the 5-HT before injection, the greater the reduction of pain intensity. The resting pain intensity reduction was not related to 5-HT. In conclusion, this study indicates a stronger short-term analgesic effect on TMJ movement pain by intra-articular administration of the 5-HT3 receptor antagonist granisetron in patients with high levels of circulating 5-HT.

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Year:  2004        PMID: 15770056      PMCID: PMC1781573          DOI: 10.1080/09629350400014123

Source DB:  PubMed          Journal:  Mediators Inflamm        ISSN: 0962-9351            Impact factor:   4.711


  13 in total

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Authors:  P Alstergren; S Kopp
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Review 2.  Receptors for 5-hydroxytryptamine: current perspectives on classification and nomenclature.

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5.  Immediate effects of the serotonin antagonist granisetron on temporomandibular joint pain in patients with systemic inflammatory disorders.

Authors:  O Voog; P Alstergren; E Leibur; R Kallikorm; S Kopp
Journal:  Life Sci       Date:  2000-12-22       Impact factor: 5.037

6.  Peripherally administered serotonin 5-HT3 receptor antagonists reduce inflammatory pain in rats.

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Journal:  Pain       Date:  2000-02       Impact factor: 6.961

8.  Impact of temporomandibular joint pain on activities of daily living in patients with rheumatoid arthritis.

Authors:  Ulle Voog; Per Alstergren; Edvitar Leibur; Riina Kallikorm; Sigvard Kopp
Journal:  Acta Odontol Scand       Date:  2003-10       Impact factor: 2.331

9.  Serotonin content of platelets in inflammatory rheumatic diseases. Correlation with clinical activity.

Authors:  J Zeller; E Weissbarth; B Baruth; H Mielke; H Deicher
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10.  Blood serotonin and joint pain in seropositive versus seronegative rheumatoid arthritis.

Authors:  Sigvard Kopp; Per Alstergren
Journal:  Mediators Inflamm       Date:  2002-08       Impact factor: 4.711

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  3 in total

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3.  Psychoeducation program on strategies for coping with stress in patients with temporomandibular joint dysfunction.

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  3 in total

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