BACKGROUND: Antiretroviral regimens for HIV-infected patients require strict adherence. Untreated depression has been associated with medication nonadherence. We proposed to evaluate the effect of antidepressant treatment (ADT) on antiretroviral adherence. METHODS: Data were retrieved for HIV-infected patients seen at an urban health care setting (1997-2001) from chart review and administrative and pharmacy files. Antiretroviral adherence was determined for depressed patients stratified by receipt of and adherence to ADT. Antiretroviral adherence was compared before and after initiation of ADT. RESULTS: Of 1713 HIV-infected patients, 57% were depressed; of those, 46% and 52% received ADT and antiretroviral treatment, respectively. Antiretroviral adherence was lower among depressed patients not on ADT (vs. those on ADT; P = 0.012). Adherence to antiretroviral treatment was higher among patients adherent to ADT (vs. those nonadherent to antidepressant treatment; P = 0.0014). Antiretroviral adherence improved over a 6-month period for adherent, nonadherent, and nonprescribed ADT groups; however, the mean pre- versus post-6-month change in antiretroviral adherence was significantly greater for those prescribed antidepressants. CONCLUSIONS: Depression was common, and antiretroviral adherence was higher for depressed patients prescribed and adherent to ADT compared with those neither prescribed nor adherent to ADT. Attention to diagnosis and treatment of depressive disorders in this population may improve antiretroviral adherence and ultimate survival.
BACKGROUND: Antiretroviral regimens for HIV-infectedpatients require strict adherence. Untreated depression has been associated with medication nonadherence. We proposed to evaluate the effect of antidepressant treatment (ADT) on antiretroviral adherence. METHODS: Data were retrieved for HIV-infectedpatients seen at an urban health care setting (1997-2001) from chart review and administrative and pharmacy files. Antiretroviral adherence was determined for depressedpatients stratified by receipt of and adherence to ADT. Antiretroviral adherence was compared before and after initiation of ADT. RESULTS: Of 1713 HIV-infectedpatients, 57% were depressed; of those, 46% and 52% received ADT and antiretroviral treatment, respectively. Antiretroviral adherence was lower among depressedpatients not on ADT (vs. those on ADT; P = 0.012). Adherence to antiretroviral treatment was higher among patients adherent to ADT (vs. those nonadherent to antidepressant treatment; P = 0.0014). Antiretroviral adherence improved over a 6-month period for adherent, nonadherent, and nonprescribed ADT groups; however, the mean pre- versus post-6-month change in antiretroviral adherence was significantly greater for those prescribed antidepressants. CONCLUSIONS:Depression was common, and antiretroviral adherence was higher for depressedpatients prescribed and adherent to ADT compared with those neither prescribed nor adherent to ADT. Attention to diagnosis and treatment of depressive disorders in this population may improve antiretroviral adherence and ultimate survival.
Authors: Glenn J Wagner; Bonnie Ghosh-Dastidar; Eric Robinson; Victoria K Ngo; Peter Glick; Barbara Mukasa; Seggane Musisi; Dickens Akena Journal: AIDS Behav Date: 2017-06
Authors: Joseph A Delaney; Robin M Nance; Bridget M Whitney; Frederick L Altice; Xinyuan Dong; Maria Esther Perez Trejo; Mika Matsuzaki; Faye S Taxman; Geetanjali Chander; Irene Kuo; Rob Fredericksen; Lauren N Strand; Joseph J Eron; Elvin Geng; Mari M Kitahata; William C Mathews; Kenneth Mayer; Richard D Moore; Michael S Saag; Sandra Springer; Redonna Chandler; Shoshana Kahana; Heidi M Crane Journal: J Acquir Immune Defic Syndr Date: 2018-11-01 Impact factor: 3.731
Authors: Jasmine Gurm; Hasina Samji; Adriana Nophal; Erin Ding; Verena Strehlau; Julia Zhu; Julio S G Montaner; Robert S Hogg; Silvia Guillemi Journal: CMAJ Open Date: 2015-04-02