| Literature DB >> 15760655 |
Donald L Gardiner1, Matthew W A Dixon, Tobias Spielmann, Tina S Skinner-Adams, Paula L Hawthorne, Maria R Ortega, David J Kemp, Katharine R Trenholme.
Abstract
Gametocytogenesis is fundamental for transmission of the malaria parasite Plasmodium falciparum from the human host to the mosquito vector, yet very little is understood about what triggers the switch between asexual reproduction and gametocytogenesis. Arresting the progression through the sexual cycle would block transmission of this disease. Here we identify a novel gene in P. falciparum that when genetically silenced reduces gametocyte production by a factor of 6, and when complemented up-regulates gametocyte-specific gene transcription.Entities:
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Year: 2005 PMID： 15760655 DOI： 10.1016/j.molbiopara.2004.12.010
Source DB: PubMed Journal: Mol Biochem Parasitol ISSN： 0166-6851 Impact factor: 1.759