OBJECTIVE: To determine whether proton magnetic resonance spectroscopy (1H-MRS) could be a useful tool for detecting microscopic diffuse axonal injury to evaluate the functional status of patients with traumatic brain injury (TBI). DESIGN: A comparative study. SETTING: An inpatient rehabilitation unit in Korea. SUBJECTS: We examined eight adult patients who had severe TBI approximately five months before. Fourteen normal controls were employed for comparison. MAIN MEASURES: Image-guided localized in vivo 1H-MRS was performed in the parietal white matter and occipital grey matter regions in brain in which no definite abnormalities in MR imaging were found at the time of 1H-MRS examination. We evaluated functional status for all patients with the Functional Independence Measure (FIM) on the same day as the 1H-MRS examination and compared the results. RESULTS: In the parietal white matter, the [N-acetyl aspartate/creatine] ratios were significantly lower, and the [choline/creatine] and [myo-inositol/creatine] ratios were significantly higher than those of normal controls. Significant correlations of the IN-acetyl aspartate/creatine] and [myo-inositol/creatine] ratios in the parietal white matter with FIM scores were observed (p < 0.05). CONCLUSIONS: A spectral feature of the decreased [N-acetyl aspartate/creatine] and increased [choline/creatine] and [myo-inositol/creatine] ratios in parietal white matter may be a marker for diffuse axonal injury in patients with TBI and has a significant correlation with the functional status of the patients. Localized 1H-MRS has the potential to be used for detecting diffuse axonal injury in vivo in TBI patients, which can be used to guide evaluation of the functional status of TBI patients receiving rehabilitation.
OBJECTIVE: To determine whether proton magnetic resonance spectroscopy (1H-MRS) could be a useful tool for detecting microscopic diffuse axonal injury to evaluate the functional status of patients with traumatic brain injury (TBI). DESIGN: A comparative study. SETTING: An inpatient rehabilitation unit in Korea. SUBJECTS: We examined eight adult patients who had severe TBI approximately five months before. Fourteen normal controls were employed for comparison. MAIN MEASURES: Image-guided localized in vivo 1H-MRS was performed in the parietal white matter and occipital grey matter regions in brain in which no definite abnormalities in MR imaging were found at the time of 1H-MRS examination. We evaluated functional status for all patients with the Functional Independence Measure (FIM) on the same day as the 1H-MRS examination and compared the results. RESULTS: In the parietal white matter, the [N-acetyl aspartate/creatine] ratios were significantly lower, and the [choline/creatine] and [myo-inositol/creatine] ratios were significantly higher than those of normal controls. Significant correlations of the IN-acetyl aspartate/creatine] and [myo-inositol/creatine] ratios in the parietal white matter with FIM scores were observed (p < 0.05). CONCLUSIONS: A spectral feature of the decreased [N-acetyl aspartate/creatine] and increased [choline/creatine] and [myo-inositol/creatine] ratios in parietal white matter may be a marker for diffuse axonal injury in patients with TBI and has a significant correlation with the functional status of the patients. Localized 1H-MRS has the potential to be used for detecting diffuse axonal injury in vivo in TBIpatients, which can be used to guide evaluation of the functional status of TBIpatients receiving rehabilitation.
Authors: Robert W Van Boven; Greg S Harrington; David B Hackney; Andreas Ebel; Grant Gauger; J Douglas Bremner; Mark D'Esposito; John A Detre; E Mark Haacke; Clifford R Jack; William J Jagust; Denis Le Bihan; Chester A Mathis; Susanne Mueller; Pratik Mukherjee; Norbert Schuff; Anthony Chen; Michael W Weiner Journal: J Rehabil Res Dev Date: 2009
Authors: Franck Amyot; David B Arciniegas; Michael P Brazaitis; Kenneth C Curley; Ramon Diaz-Arrastia; Amir Gandjbakhche; Peter Herscovitch; Sidney R Hinds; Geoffrey T Manley; Anthony Pacifico; Alexander Razumovsky; Jason Riley; Wanda Salzer; Robert Shih; James G Smirniotopoulos; Derek Stocker Journal: J Neurotrauma Date: 2015-09-30 Impact factor: 5.269
Authors: Su Xu; Jiachen Zhuo; Jennifer Racz; Da Shi; Steven Roys; Gary Fiskum; Rao Gullapalli Journal: J Neurotrauma Date: 2011-09-29 Impact factor: 5.269
Authors: Nicole D Osier; Melody Ziari; Ava M Puccio; Samuel Poloyac; David O Okonkwo; Margaret B Minnigh; Sue R Beers; Yvette P Conley Journal: Brain Inj Date: 2019-07-15 Impact factor: 2.311
Authors: Matthew G Stovell; Jiun-Lin Yan; Alison Sleigh; Marius O Mada; T Adrian Carpenter; Peter J A Hutchinson; Keri L H Carpenter Journal: Front Neurol Date: 2017-09-12 Impact factor: 4.003
Authors: Hemali Panchal; Nico Sollmann; Ofer Pasternak; Michael L Alosco; Philipp Kinzel; David Kaufmann; Elisabeth Hartl; Lorie A Forwell; Andrew M Johnson; Elaine N Skopelja; Martha E Shenton; Inga K Koerte; Paul S Echlin; Alexander P Lin Journal: Front Neurol Date: 2018-08-20 Impact factor: 4.003
Authors: Tim P Lawrence; Adam Steel; Martyn Ezra; Mhairi Speirs; Pieter M Pretorius; Gwenaelle Douaud; Stamatios Sotiropoulos; Tom Cadoux-Hudson; Uzay E Emir; Natalie L Voets Journal: Brain Inj Date: 2019-03-08 Impact factor: 2.311