Literature DB >> 15758664

Epithelial differentiation in pancreatic development and neoplasia: new niches for nestin and Notch.

Steven D Leach1.   

Abstract

Changes in epithelial differentiation represent a characteristic early feature of human pancreatic cancer. Recent work suggests that many of these changes may reflect a pathologic recapitulation of developmental events. Reflecting this principle, metaplastic and neoplastic pancreatic epithelium appear to share many features in common with embryonic pancreatic epithelium, including reactivation of the Notch signaling pathway. In this review, we summarize recent studies involving regulation of epithelial differentiation in both embryonic and adult pancreas and highlight the role of Notch in regulating an exocrine progenitor pool.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15758664     DOI： 10.1097/01.mcg.0000155547.83901.a3

Source DB:  PubMed          Journal:  J Clin Gastroenterol        ISSN： 0192-0790            Impact factor:   3.062


  14 in total

Review 1.  Biology and management of pancreatic cancer.

Authors:  Paula Ghaneh; Eithne Costello; John P Neoptolemos
Journal:  Gut       Date:  2007-08       Impact factor: 23.059

Review 2.  Advanced pancreatic adenocarcinoma: a review of current treatment strategies and developing therapies.

Authors:  Andrea Teague; Kian-Huat Lim; Andrea Wang-Gillam
Journal:  Ther Adv Med Oncol       Date:  2015-03       Impact factor: 8.168

3.  Evidence of unrestrained beta-cell proliferation and neogenesis in a patient with hyperinsulinemic hypoglycemia after gastric bypass surgery.

Authors:  Nidheesh Dadheech; Dominique Garrel; Jean Buteau
Journal:  Islets       Date:  2018-10-12       Impact factor: 2.694

Review 4.  On the diabetic menu: zebrafish as a model for pancreas development and function.

Authors:  Mary D Kinkel; Victoria E Prince
Journal:  Bioessays       Date:  2009-02       Impact factor: 4.345

Review 5.  Pancreatic cancer.

Authors:  Anirban Maitra; Ralph H Hruban
Journal:  Annu Rev Pathol       Date:  2008       Impact factor: 23.472

Review 6.  Pancreatic cancer stem cells: new understanding of tumorigenesis, clinical implications.

Authors:  Ivan Ischenko; Hendrik Seeliger; Axel Kleespies; Martin K Angele; Martin E Eichhorn; Karl-Walter Jauch; Christiane J Bruns
Journal:  Langenbecks Arch Surg       Date:  2009-05-07       Impact factor: 3.445

Review 7.  Challenges and advances in mouse modeling for human pancreatic tumorigenesis and metastasis.

Authors:  Wanglong Qiu; Gloria H Su
Journal:  Cancer Metastasis Rev       Date:  2013-06       Impact factor: 9.264

8.  A concise review on the current understanding of pancreatic cancer stem cells.

Authors:  Arokia Priyanka Vaz; Moorthy P Ponnusamy; Parthasarathy Seshacharyulu; Surinder K Batra
Journal:  J Cancer Stem Cell Res       Date:  2014

Review 9.  Molecular targets for the treatment of pancreatic cancer: Clinical and experimental studies.

Authors:  Tasuku Matsuoka; Masakazu Yashiro
Journal:  World J Gastroenterol       Date:  2016-01-14       Impact factor: 5.742

10.  Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice.

Authors:  Nils Habbe; Guanglu Shi; Robert A Meguid; Volker Fendrich; Farzad Esni; Huiping Chen; Georg Feldmann; Doris A Stoffers; Stephen F Konieczny; Steven D Leach; Anirban Maitra
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-21       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.