| Literature DB >> 15757607 |
Stavroula N Psychari1, Thomas S Apostolou, Loukas Sinos, Eftihia Hamodraka, George Liakos, Dimitrios Th Kremastinos.
Abstract
Previous studies have demonstrated inflammation to be a risk factor in patients with atrial fibrillation (AF). In this prospective study of 90 patients with persistent and permanent AF and 46 controls, we found increased C-reactive protein (CRP) and interleukin-6 levels in patients with AF compared with controls (p <0.001). Multivariate analysis revealed CRP to be an independent predictor of AF (p = 0.01). Left atrial diameter was positively related to CRP and interleukin-6 (p <0.001, R = 0.37; p <0.001, R = 0.46, respectively) and negatively related to left ventricular function. Interleukin-6 levels were positively related to AF duration before cardioversion (p = 0.02). Elevation of CRP and interleukin-6 suggest a role of inflammation in AF, and the relation of CRP and interleukin-6 to left atrial size and AF duration before cardioversion indicates that inflammation may participate in the process of atrial remodeling.Entities:
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Year: 2005 PMID： 15757607 DOI： 10.1016/j.amjcard.2004.11.032
Source DB: PubMed Journal: Am J Cardiol ISSN： 0002-9149 Impact factor: 2.778