Literature DB >> 1575709

Accessory protein function in the DNA polymerase III holoenzyme from E. coli.

M O'Donnell1.   

Abstract

DNA polymerases which duplicate cellular chromosomes are multiprotein complexes. The individual functions of the many proteins required to duplicate a chromosome are not fully understood. The multiprotein complex which duplicates the Escherichia coli chromosome, DNA polymerase III holoenzyme (holoenzyme), contains a DNA polymerase subunit and nine accessory proteins. This report summarizes our current understanding of the individual functions of the accessory proteins within the holoenzyme, lending insight into why a chromosomal replicase needs such a complex structure.

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Year:  1992        PMID： 1575709     DOI： 10.1002/bies.950140206

Source DB:  PubMed          Journal:  Bioessays        ISSN： 0265-9247            Impact factor:   4.345


  5 in total

Review 1.  The sliding clamp of DNA polymerase III holoenzyme encircles DNA.

Authors:  M O'Donnell; J Kuriyan; X P Kong; P T Stukenberg; R Onrust
Journal:  Mol Biol Cell       Date:  1992-09       Impact factor: 4.138

2.  Out-of-plane motions in open sliding clamps: molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigen.

Authors:  Steven L Kazmirski; Yanxiang Zhao; Gregory D Bowman; Mike O'donnell; John Kuriyan
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-16       Impact factor: 11.205

3.  Cloning of the large subunit of activator 1 (replication factor C) reveals homology with bacterial DNA ligases.

Authors:  P D Burbelo; A Utani; Z Q Pan; Y Yamada
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-15       Impact factor: 11.205

4.  Assembly of a functional replication complex without ATP hydrolysis: a direct interaction of bacteriophage T4 gp45 with T4 DNA polymerase.

Authors:  M K Reddy; S E Weitzel; P H von Hippel
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-15       Impact factor: 11.205

5.  Assembly of a processive messenger RNA polyadenylation complex.

Authors:  S Bienroth; W Keller; E Wahle
Journal:  EMBO J       Date:  1993-02       Impact factor: 11.598
  5 in total

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