Literature DB >> 1575548

Increased plasma tumour necrosis factor-alpha concentration in atopic dermatitis.

S Sumimoto1, M Kawai, Y Kasajima, T Hamamoto.   

Abstract

Plasma tumour necrosis factor-alpha (TNF-alpha) was measured in 15 children with atopic dermatitis, 13 children with bronchial asthma, and 11 healthy controls. Plasma TNF-alpha concentration was increased in atopic dermatitis and the magnitude of the increase was correlated with the severity of the dermatitis but TNF-alpha concentration was not increased in bronchial asthma. A significant correlation was found between plasma TNF-alpha and plasma histamine concentrations in atopic dermatitis. The data suggest that the overproduction of TNF-alpha is associated with increased plasma histamine concentration, and might play a part in the pathophysiological mechanism of atopic dermatitis.

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Year:  1992        PMID: 1575548      PMCID: PMC1793658          DOI: 10.1136/adc.67.3.277

Source DB:  PubMed          Journal:  Arch Dis Child        ISSN: 0003-9888            Impact factor:   3.791


  15 in total

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Authors:  H A Sampson; K R Broadbent; J Bernhisel-Broadbent
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  15 in total

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