Literature DB >> 1575019

Expression of stress-response (heat-shock) protein 27 in human brain tumors: an immunohistochemical study.

M Kato1, F Herz, S Kato, A Hirano.   

Abstract

This report concerns the expression of the low molecular weight stress-response (heat-shock) protein 27 (srp 27) in a variety of human brain tumors. Immunohistochemical techniques were used; cells of the breast cancer line MCF7 served as positive controls. The reaction product was found exclusively in the cytoplasm. Srp 27 was detected in 5/5 breast tumor metastases to the brain and in 5/21 meningiomas. The protein was also detected in 5/11 glioblastomas and 2/5 pituitary adenomas. By comparison, positive staining was observed in only 1/15 astrocytomas and 1/7 medulloblastoma and no reaction was seen with the oligodendrogliomas, schwannomas and gangliogliomas tested. These observations demonstrate that srp 27 is expressed by certain primary intracranial tumors.

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Year:  1992        PMID： 1575019     DOI： 10.1007/bf00713535

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


  25 in total

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Journal:  Annu Rev Genet       Date:  1988       Impact factor: 16.830

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Authors:  L McAlister; D B Finkelstein
Journal:  Biochem Biophys Res Commun       Date:  1980-04-14       Impact factor: 3.575

6.  Presence of an estrogen-regulated protein in endometrial cancer.

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Journal:  Obstet Gynecol       Date:  1985-09       Impact factor: 7.661

7.  Identification of two related markers for common acute lymphoblastic leukemia as heat shock proteins.

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Journal:  J Clin Invest       Date:  1990-01       Impact factor: 14.808

8.  Estrogen-receptor protein in intracranial meningiomas.

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Journal:  J Neurosurg       Date:  1979-04       Impact factor: 5.115

9.  Stress response protein (srp-27) determination in primary human breast carcinomas: clinical, histologic, and prognostic correlations.

Authors:  A Thor; C Benz; D Moore; E Goldman; S Edgerton; J Landry; L Schwartz; B Mayall; E Hickey; L A Weber
Journal:  J Natl Cancer Inst       Date:  1991-02-06       Impact factor: 13.506

10.  Ecdysterone receptor is a sequence-specific transcription factor involved in the developmental regulation of heat shock genes.

Authors:  Y Luo; J Amin; R Voellmy
Journal:  Mol Cell Biol       Date:  1991-07       Impact factor: 4.272
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  14 in total

1.  Stress-response proteins in human pituitary adenomas. Expression of heat-shock protein 72 (HSP-72).

Authors:  G Kontogeorgos; L Stefaneanu; K Kovacs
Journal:  Endocrine       Date:  1997-02       Impact factor: 3.633

2.  Pathological characterization of astrocytic hyaline inclusions in familial amyotrophic lateral sclerosis.

Authors:  S Kato; H Hayashi; K Nakashima; E Nanba; M Kato; A Hirano; I Nakano; K Asayama; E Ohama
Journal:  Am J Pathol       Date:  1997-08       Impact factor: 4.307

3.  Divergent effects of hyperosmolality on stress-response (heat shock) protein expression in cultured human tumor cells: an immunocytochemical study.

Authors:  M Kato; F Herz; D Brijlall; S Kato
Journal:  Experientia       Date:  1994-05-15

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Authors:  K Renkawek; G J Bosman; W W de Jong
Journal:  Acta Neuropathol       Date:  1994       Impact factor: 17.088

5.  Alexander's disease in a Bernese mountain dog.

Authors:  H Weissenböck; G Obermaier; E Dahme
Journal:  Acta Neuropathol       Date:  1996       Impact factor: 17.088

6.  Small heat-shock protein is expressed in meningiomas and in granulofilamentous inclusion bodies.

Authors:  N Yokoyama; T Iwaki; J E Goldman; J Tateishi; M Fukui
Journal:  Acta Neuropathol       Date:  1993       Impact factor: 17.088

7.  Ultrastructural and immunohistochemical studies on ballooned cortical neurons in Creutzfeldt-Jakob disease: expression of alpha B-crystallin, ubiquitin and stress-response protein 27.

Authors:  S Kato; A Hirano; T Umahara; J F Llena; F Herz; E Ohama
Journal:  Acta Neuropathol       Date:  1992       Impact factor: 17.088

8.  Effect of hyperosmolality on alkaline phosphatase and stress-response protein 27 of MCF-7 breast cancer cells.

Authors:  M Kato; D Brijlall; S A Adler; S Kato; F Herz
Journal:  Breast Cancer Res Treat       Date:  1992       Impact factor: 4.872

9.  Expression of the small heat shock protein (hsp) 27 in human astrocytomas correlates with histologic grades and tumor growth fractions.

Authors:  H Khalid; K Tsutsumi; H Yamashita; M Kishikawa; A Yasunaga; S Shibata
Journal:  Cell Mol Neurobiol       Date:  1995-04       Impact factor: 5.046

10.  Heat-Shock Stress-Response Proteins in Endocrine Pathology.

Authors:  George Kontogeorgos; Kalman Kovacs; Sylvia L. Asa
Journal:  Endocr Pathol       Date:  1995       Impact factor: 3.943
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