Literature DB >> 1575002

Effect of salicylic acid and calcium on mitochondrial functions.

Y Yoshida1, I Singh, C P Darby.   

Abstract

The rapid mitochondrial uptake of calcium followed by slow release in certain pathophysiological states associated with an increase in intracellular calcium, to normalize the cytoplasmic levels of free calcium, provides an important protective mechanism against calcium cellular toxicity. Salicylic acid, an in vivo metabolite of aspirin, inhibits the uptake and enhances the release of calcium by mitochondria, thereby increasing the levels of cytoplasmic free calcium. The Ca2+ induced mitochondrial swelling is enhanced in the presence of salicylic acid and in which turn leads to loss of biosynthesis of ATP. These results suggest that salicylic acid may promote cellular damage in pathophysiological states associated with increase in intracellular free calcium.

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Year:  1992        PMID： 1575002     DOI： 10.1111/j.1600-0404.1992.tb04026.x

Source DB:  PubMed          Journal:  Acta Neurol Scand        ISSN： 0001-6314            Impact factor:   3.209


  5 in total

1.  Rebamipide significantly inhibits indomethacin-induced mitochondrial damage, lipid peroxidation, and apoptosis in gastric epithelial RGM-1 cells.

Authors:  Yumiko Nagano; Hirofumi Matsui; Mutsumi Muramatsu; Osamu Shimokawa; Takeshi Shibahara; Akinori Yanaka; Akira Nakahara; Yasushi Matsuzaki; Naomi Tanaka; Yukio Nakamura
Journal:  Dig Dis Sci       Date:  2005-10       Impact factor: 3.199

2.  Gastric acid induces mitochondrial superoxide production and lipid peroxidation in gastric epithelial cells.

Authors:  Hirofumi Matsui; Yumiko Nagano; Osamu Shimokawa; Tsuyoshi Kaneko; Kanho Rai; Jumpei Udo; Aki Hirayama; Yukio Nakamura; Hiroko P Indo; Hideyuki J Majima; Ichinosuke Hyodo
Journal:  J Gastroenterol       Date:  2011-07-26       Impact factor: 7.527

3.  Early alterations in mitochondrial reserve capacity; a means to predict subsequent photoreceptor cell death.

Authors:  Nathan R Perron; Craig Beeson; Bärbel Rohrer
Journal:  J Bioenerg Biomembr       Date:  2012-10-23       Impact factor: 2.945

4.  New formulation of old aspirin for better delivery.

Authors:  Akil A Kalathil; Anil Kumar; Bhabatosh Banik; Timothy A Ruiter; Rakesh K Pathak; Shanta Dhar
Journal:  Chem Commun (Camb)       Date:  2016-01-04       Impact factor: 6.222

5.  The pathophysiology of non-steroidal anti-inflammatory drug (NSAID)-induced mucosal injuries in stomach and small intestine.

Authors:  Hirofumi Matsui; Osamu Shimokawa; Tsuyoshi Kaneko; Yumiko Nagano; Kanho Rai; Ichinosuke Hyodo
Journal:  J Clin Biochem Nutr       Date:  2011-02-26       Impact factor: 3.114
  5 in total

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