BACKGROUND: The gene encoding oestrogen receptor alpha (ESR1) appears to regulate bone mineral density (BMD) and other determinants of osteoporotic fracture risk. OBJECTIVE: To investigate the relation between common polymorphisms and haplotypes of the ESR1 gene and osteoporosis related phenotypes in a population based cohort of 3054 Scottish women. RESULTS: There was a significant association between a common haplotype "px", defined by the PvuII and XbaI restriction fragment length polymorphisms within intron 1 of the ESR1 gene, and femoral neck bone loss in postmenopausal women who had not received hormone replacement therapy (n = 945; p = 0.009). Annual rates of femoral neck bone loss were approximately 14% higher in subjects who carried one copy of px and 22% higher in those who carried two copies, compared with those who did not carry the px haplotype. The px haplotype was associated with lower femoral neck BMD in the postmenopausal women (p = 0.02), and with reduced calcaneal broadband ultrasound attenuation (BUA) values in the whole study population (p = 0.005). There was no association between a TA repeat polymorphism in the ESR1 promoter and any phenotype studied, though on long range haplotype analysis subjects with a smaller number of TA repeats who also carried the px haplotype had reduced BUA values. CONCLUSIONS: The ESR1px haplotype is associated with reduced hip BMD values and increased rates of femoral neck bone loss in postmenopausal women. An association with BUA may explain the fact that ESR1 intron 1 alleles predict osteoporotic fractures by a mechanism partly independent of differences in BMD.
BACKGROUND: The gene encoding oestrogen receptor alpha (ESR1) appears to regulate bone mineral density (BMD) and other determinants of osteoporotic fracture risk. OBJECTIVE: To investigate the relation between common polymorphisms and haplotypes of the ESR1 gene and osteoporosis related phenotypes in a population based cohort of 3054 Scottish women. RESULTS: There was a significant association between a common haplotype "px", defined by the PvuII and XbaI restriction fragment length polymorphisms within intron 1 of the ESR1 gene, and femoral neck bone loss in postmenopausal women who had not received hormone replacement therapy (n = 945; p = 0.009). Annual rates of femoral neck bone loss were approximately 14% higher in subjects who carried one copy of px and 22% higher in those who carried two copies, compared with those who did not carry the px haplotype. The px haplotype was associated with lower femoral neck BMD in the postmenopausal women (p = 0.02), and with reduced calcaneal broadband ultrasound attenuation (BUA) values in the whole study population (p = 0.005). There was no association between a TA repeat polymorphism in the ESR1 promoter and any phenotype studied, though on long range haplotype analysis subjects with a smaller number of TA repeats who also carried the px haplotype had reduced BUA values. CONCLUSIONS: The ESR1px haplotype is associated with reduced hip BMD values and increased rates of femoral neck bone loss in postmenopausal women. An association with BUA may explain the fact that ESR1 intron 1 alleles predict osteoporotic fractures by a mechanism partly independent of differences in BMD.
Authors: S G Wilson; P W Reed; A Bansal; M Chiano; M Lindersson; M Langdown; R L Prince; D Thompson; E Thompson; M Bailey; P W Kleyn; P Sambrook; M M Shi; T D Spector Journal: Am J Hum Genet Date: 2002-12-11 Impact factor: 11.025
Authors: S G Wilson; P W Reed; T Andrew; M J Barber; M Lindersson; M Langdown; D Thompson; E Thompson; M Bailey; M Chiano; P W Kleyn; T D Spector Journal: J Bone Miner Res Date: 2003-12-16 Impact factor: 6.741
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Authors: S R Cummings; D M Black; M C Nevitt; W Browner; J Cauley; K Ensrud; H K Genant; L Palermo; J Scott; T M Vogt Journal: Lancet Date: 1993-01-09 Impact factor: 79.321
Authors: Kay-Tee Khaw; Jonathan Reeve; Robert Luben; Sheila Bingham; Ailsa Welch; Nicholas Wareham; Suzy Oakes; Nicholas Day Journal: Lancet Date: 2004-01-17 Impact factor: 79.321
Authors: Unnur Styrkarsdottir; Jean-Baptiste Cazier; Augustine Kong; Ottar Rolfsson; Helene Larsen; Emma Bjarnadottir; Vala D Johannsdottir; Margret S Sigurdardottir; Yu Bagger; Claus Christiansen; Inga Reynisdottir; Struan F A Grant; Kristjan Jonasson; Michael L Frigge; Jeffrey R Gulcher; Gunnar Sigurdsson; Kari Stefansson Journal: PLoS Biol Date: 2003-11-03 Impact factor: 8.029
Authors: Gregory J Tranah; Brent C Taylor; Li-Yung Lui; Joseph M Zmuda; Jane A Cauley; Kristine E Ensrud; Teresa A Hillier; Marc C Hochberg; Jia Li; Brian K Rhees; Henry A Erlich; Mark D Sternlicht; Gary Peltz; Steven R Cummings Journal: Calcif Tissue Int Date: 2008-09-12 Impact factor: 4.333