BACKGROUND: The vitamin D receptor (VDR) gene is important to human stature, as it mediates metabolic pathways, calcium homeostasis, and phosphate homeostasis, which influence growth. METHODS: We examined the relationship between VDR and adult height in 1873 white subjects from 406 nuclear families. Four SNPs, namely -4817A/G at intron 1, FokI C/T at exon 2 start codon, BsmI A/G at intron 8, and TaqI T/C at exon 9 in VDR were tested for linkage and association with adult height variation by the program QTDT (quantitative transmission disequilibrium test). The bT haplotype of the BsmI and TaqI loci was further tested for its association with height in unrelated samples randomly chosen from the 406 nuclear families by traditional population association methods. RESULTS: All four tested SNPs were linked to adult height. Within family associations with height were detected at BsmI and TaqI loci (p = 0.048 and 0.039, respectively). Analyses based on BsmI/TaqI haplotypes also revealed evidence for linkage (p = 0.05) and association (p = 0.001) with height. The bT haplotype was significantly associated with higher adult height (p = 0.033, within family association test). Such an association might be female specific and influenced by menstrual status. CONCLUSIONS: Our results strongly suggest that VDR may be linked to and associated with adult height variation in white populations.
BACKGROUND: The vitamin D receptor (VDR) gene is important to human stature, as it mediates metabolic pathways, calcium homeostasis, and phosphate homeostasis, which influence growth. METHODS: We examined the relationship between VDR and adult height in 1873 white subjects from 406 nuclear families. Four SNPs, namely -4817A/G at intron 1, FokI C/T at exon 2 start codon, BsmI A/G at intron 8, and TaqI T/C at exon 9 in VDR were tested for linkage and association with adult height variation by the program QTDT (quantitative transmission disequilibrium test). The bT haplotype of the BsmI and TaqI loci was further tested for its association with height in unrelated samples randomly chosen from the 406 nuclear families by traditional population association methods. RESULTS: All four tested SNPs were linked to adult height. Within family associations with height were detected at BsmI and TaqI loci (p = 0.048 and 0.039, respectively). Analyses based on BsmI/TaqI haplotypes also revealed evidence for linkage (p = 0.05) and association (p = 0.001) with height. The bT haplotype was significantly associated with higher adult height (p = 0.033, within family association test). Such an association might be female specific and influenced by menstrual status. CONCLUSIONS: Our results strongly suggest that VDR may be linked to and associated with adult height variation in white populations.
Authors: Jianfeng Xu; Eugene R Bleecker; Hajo Jongepier; Timothy D Howard; Gerard H Koppelman; Dirkje S Postma; Deborah A Meyers Journal: Am J Hum Genet Date: 2002-07-15 Impact factor: 11.025
Authors: Steven Wiltshire; Timothy M Frayling; Andrew T Hattersley; Graham A Hitman; Mark Walker; Jonathan C Levy; Stephen O'Rahilly; Christopher J Groves; Stephan Menzel; Lon R Cardon; Mark I McCarthy Journal: Am J Hum Genet Date: 2001-12-20 Impact factor: 11.025
Authors: André G Uitterlinden; Yue Fang; Arjan P Bergink; Joyce B J van Meurs; Hans P T M van Leeuwen; Huibert A P Pols Journal: Mol Cell Endocrinol Date: 2002-11-29 Impact factor: 4.102
Authors: Mara Ferrara; Sofia M R Matarese; Matteo Francese; Barbara Borrelli; Antonietta Coppola; Lina Coppola; Luigi Esposito Journal: Br J Haematol Date: 2002-05 Impact factor: 6.998
Authors: I M van der Sluis; S M P F de Muinck Keizer-Schrama; E P Krenning; H A P Pols; A G Uitterlinden Journal: Calcif Tissue Int Date: 2003-07-24 Impact factor: 4.333
Authors: Stephanie C E Schuit; Joyce B J van Meurs; Arjan P Bergink; Marjolein van der Klift; Yue Fang; Geraline Leusink; Albert Hofman; Johannes P T M van Leeuwen; André G Uitterlinden; Huibert A P Pols Journal: J Clin Endocrinol Metab Date: 2004-01 Impact factor: 5.958
Authors: David J Hughes; Ivona Hlavatá; Pavel Soucek; Barbara Pardini; Alessio Naccarati; Ludmila Vodickova; Mazda Jenab; Pavel Vodicka Journal: J Gastrointest Cancer Date: 2011-09
Authors: Bradford Towne; Kimberly D Williams; John Blangero; Stefan A Czerwinski; Ellen W Demerath; Ramzi W Nahhas; Thomas D Dyer; Shelley A Cole; Miryoung Lee; Audrey C Choh; Dana L Duren; Richard J Sherwood; William Cameron Chumlea; Roger M Siervogel Journal: Hum Biol Date: 2008-12 Impact factor: 0.553
Authors: Seo Kyung Choi; Mun Suk Park; Jun Kyu Song; Kyung Sik Yoon; Kyung Lim Yoon; Kye Shik Shim Journal: J Korean Med Sci Date: 2013-08-28 Impact factor: 2.153
Authors: Akiah Ottesen Berg; Kjetil N Jørgensen; Mari Nerhus; Lavinia Athanasiu; Alice B Popejoy; Francesco Bettella; Linn Christin Bonaventure Norbom; Tiril P Gurholt; Sandra R Dahl; Ole A Andreassen; Srdjan Djurovic; Ingrid Agartz; Ingrid Melle Journal: PLoS One Date: 2018-08-24 Impact factor: 3.240