Literature DB >> 15743969

A mutation in the decoding center of Thermus thermophilus 16S rRNA suggests a novel mechanism of streptomycin resistance.

Steven T Gregory1, Jennifer F Carr, Albert E Dahlberg.   

Abstract

A spontaneous kanamycin resistance and capreomycin resistance mutation, A1408G, in the decoding center of 16S rRNA, was identified in the extreme thermophile Thermus thermophilus. Unexpectedly, this mutation also confers resistance to streptomycin. We propose a novel mechanism of streptomycin resistance by which A1408G influences conformational changes in 16S rRNA during tRNA selection.

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Year:  2005        PMID： 15743969      PMCID： PMC1064055          DOI： 10.1128/JB.187.6.2200-2202.2005

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  23 in total

1.  Structure of the 30S ribosomal subunit.

Authors:  B T Wimberly; D E Brodersen; W M Clemons; R J Morgan-Warren; A P Carter; C Vonrhein; T Hartsch; V Ramakrishnan
Journal:  Nature       Date:  2000-09-21       Impact factor: 49.962

2.  Selection of tRNA by the ribosome requires a transition from an open to a closed form.

Authors:  James M Ogle; Frank V Murphy; Michael J Tarry; V Ramakrishnan
Journal:  Cell       Date:  2002-11-27       Impact factor: 41.582

3.  Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium.

Authors:  J Björkman; P Samuelsson; D I Andersson; D Hughes
Journal:  Mol Microbiol       Date:  1999-01       Impact factor: 3.501

4.  A single 16S ribosomal RNA substitution is responsible for resistance to amikacin and other 2-deoxystreptamine aminoglycosides in Mycobacterium abscessus and Mycobacterium chelonae.

Authors:  T Prammananan; P Sander; B A Brown; K Frischkorn; G O Onyi; Y Zhang; E C Böttger; R J Wallace
Journal:  J Infect Dis       Date:  1998-06       Impact factor: 5.226

5.  Spontaneous erythromycin resistance mutation in a 23S rRNA gene, rrlA, of the extreme thermophile Thermus thermophilus IB-21.

Authors:  S T Gregory; J H Cate; A E Dahlberg
Journal:  J Bacteriol       Date:  2001-07       Impact factor: 3.490

6.  Basis for prokaryotic specificity of action of aminoglycoside antibiotics.

Authors:  M I Recht; S Douthwaite; J D Puglisi
Journal:  EMBO J       Date:  1999-06-01       Impact factor: 11.598

7.  Streptomycin-resistant and streptomycin-dependent mutants of the extreme thermophile Thermus thermophilus.

Authors:  S T Gregory; J H Cate; A E Dahlberg
Journal:  J Mol Biol       Date:  2001-06-01       Impact factor: 5.469

8.  Streptomycin interferes with conformational coupling between codon recognition and GTPase activation on the ribosome.

Authors:  Kirill B Gromadski; Marina V Rodnina
Journal:  Nat Struct Mol Biol       Date:  2004-03-07       Impact factor: 15.369

9.  Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site.

Authors:  Quentin Vicens; Eric Westhof
Journal:  Chem Biol       Date:  2002-06

10.  Genetic transformation of the extreme thermophile Thermus thermophilus and of other Thermus spp.

Authors:  Y Koyama; T Hoshino; N Tomizuka; K Furukawa
Journal:  J Bacteriol       Date:  1986-04       Impact factor: 3.490
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  7 in total

1.  Mutational analysis of 16S and 23S rRNA genes of Thermus thermophilus.

Authors:  Steven T Gregory; Jennifer F Carr; Daniel Rodriguez-Correa; Albert E Dahlberg
Journal:  J Bacteriol       Date:  2005-07       Impact factor: 3.490

Review 2.  Destination of aminoglycoside antibiotics in the 'post-antibiotic era'.

Authors:  Yoshiaki Takahashi; Masayuki Igarashi
Journal:  J Antibiot (Tokyo)       Date:  2017-10-25       Impact factor: 2.649

3.  Genetic and structural analysis of base substitutions in the central pseudoknot of Thermus thermophilus 16S ribosomal RNA.

Authors:  Steven T Gregory; Albert E Dahlberg
Journal:  RNA       Date:  2009-02       Impact factor: 4.942

4.  Identification of the biosynthetic gene cluster and an additional gene for resistance to the antituberculosis drug capreomycin.

Authors:  Elizabeth A Felnagle; Michelle R Rondon; Andrew D Berti; Heidi A Crosby; Michael G Thomas
Journal:  Appl Environ Microbiol       Date:  2007-05-11       Impact factor: 4.792

5.  Selection of peptides that target the aminoacyl-tRNA site of bacterial 16S ribosomal RNA.

Authors:  Mei Li; Anne-Cécile E Duc; Edvin Klosi; Srividya Pattabiraman; Mark R Spaller; Christine S Chow
Journal:  Biochemistry       Date:  2009-09-08       Impact factor: 3.162

6.  Structural analysis of base substitutions in Thermus thermophilus 16S rRNA conferring streptomycin resistance.

Authors:  Hasan Demirci; Frank V Murphy; Eileen L Murphy; Jacqueline L Connetti; Albert E Dahlberg; Gerwald Jogl; Steven T Gregory
Journal:  Antimicrob Agents Chemother       Date:  2014-05-12       Impact factor: 5.191

7.  A structural basis for streptomycin-induced misreading of the genetic code.

Authors:  Hasan Demirci; Frank Murphy; Eileen Murphy; Steven T Gregory; Albert E Dahlberg; Gerwald Jogl
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919
  7 in total

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