Literature DB >> 15738964

Folic acid - vitamin and panacea or genetic time bomb?

Mark Lucock1, Zoë Yates.   

Abstract

We live in a health-conscious age - many of us supplement our diet with essential micronutrients through the discretionary use of multivitamin pills or judicious selection of foods that have a health benefit beyond that conferred by the nutrient content alone - the so-called 'functional foods'. Indeed, the citizens of some nations have little choice, with a mandatory fortification policy in place for certain vitamins. But do we ever stop to consider the consequences of an increased exposure to micronutrients? We examine this issue in relation to the B-group vitamin folic acid, and ask whether supplementation with this vitamin could introduce a strong genetic selection pressure - one that has the side effect of increasing the prevalence of some of the most significant, human life-threatening diseases. Are we affecting our genetics - is this a case of human evolution in progress by altering our diet?

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Year:  2005        PMID: 15738964     DOI: 10.1038/nrg1558

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN: 1471-0056            Impact factor:   53.242


  22 in total

Review 1.  Nutrigenomics: integrating genomic approaches into nutrition research.

Authors:  Lynnette R Ferguson
Journal:  Mol Diagn Ther       Date:  2006       Impact factor: 4.074

2.  Folate: a magic bullet or a double edged sword for colorectal cancer prevention?

Authors:  Y-I Kim
Journal:  Gut       Date:  2006-10       Impact factor: 23.059

3.  MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series.

Authors:  Edouard J Servy; Laetitia Jacquesson-Fournols; Marc Cohen; Yves J R Menezo
Journal:  J Assist Reprod Genet       Date:  2018-06-07       Impact factor: 3.412

4.  Theory of the origin, evolution, and nature of life.

Authors:  Erik D Andrulis
Journal:  Life (Basel)       Date:  2011-12-23

5.  Lifestyle and diet in people using dietary supplements: a German cohort study.

Authors:  Annika Reinert; Sabine Rohrmann; Nikolaus Becker; Jakob Linseisen
Journal:  Eur J Nutr       Date:  2007-03-21       Impact factor: 5.614

6.  A humanized mouse model for the reduced folate carrier.

Authors:  David Patterson; Christine Graham; Christina Cherian; Larry H Matherly
Journal:  Mol Genet Metab       Date:  2007-11-05       Impact factor: 4.797

7.  A retrospective cohort study of the association of anesthesia and hernia repair surgery with behavioral and developmental disorders in young children.

Authors:  Charles DiMaggio; Lena S Sun; Athina Kakavouli; Mary W Byrne; Guohua Li
Journal:  J Neurosurg Anesthesiol       Date:  2009-10       Impact factor: 3.956

8.  Genetic selection? A study of individual variation in the enzymes of folate metabolism.

Authors:  Barbara A Jennings; Gavin A Willis; Jane Skinner; Caroline L Relton
Journal:  BMC Med Genet       Date:  2010-02-01       Impact factor: 2.103

Review 9.  The Pediatric Methionine Requirement Should Incorporate Remethylation Potential and Transmethylation Demands.

Authors:  Jason L Robinson; Robert F Bertolo
Journal:  Adv Nutr       Date:  2016-05-16       Impact factor: 8.701

10.  Folate biofortification of tomato fruit.

Authors:  Rocío I Díaz de la Garza; Jesse F Gregory; Andrew D Hanson
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-05       Impact factor: 11.205

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