| Literature DB >> 15734571 |
Abstract
Proteins encoded by mobile genetic elements occasionally assume cellular roles. Telomerase, for example, is a reverse transcriptase that replicates chromosome ends, and Rag1 is a transposase that mediates immunoglobulin gene rearrangements. In this article, we report cellular genes related to integrases that are not associated with a retrovirus or retrotransposon. These integrases are found in diverse eukaryotes and are evolving under functional constraint. We propose that the cellular integrases have assumed a host role and, like their retroelement counterparts, probably function in DNA metabolism.Entities:
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Year: 2005 PMID： 15734571 DOI： 10.1016/j.tig.2005.01.006
Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639