PURPOSE: Determine if gender differences in osteoarthritis relate to cytokine and growth factor levels. METHODS: Cross-sectional comparison of serum and synovial concentrations of cytokines (IL-1alphabeta, TNF-alpha, IL-6), growth factors (IGF-I, TGF-beta, IRAP), physical performance and perceived function in total knee arthroplasty candidates (TKAC) (n=17) and healthy controls (n=21) was done. RESULTS: Serum IGF-I values were reduced in female (TKAC 137.6+/-7.2; Controls 160.2+/-26.2) but not male TKAC (TKAC 182.6+/-18.4; Controls 184.0+/-18.4) (p<0.05).). Serum and synovial levels of cytokines and growth factors did not differ significantly by group or gender. Physical performance testing (SPW, TUG) revealed significant group and gender differences (p=0.001) with women demonstrating greater functional impairment. DISCUSSION: A systemic, not local component to OA pathophysiology may exist for female TKAC. Male TKAC were less impaired, and their IGF-I levels differ little from Control values.
PURPOSE: Determine if gender differences in osteoarthritis relate to cytokine and growth factor levels. METHODS: Cross-sectional comparison of serum and synovial concentrations of cytokines (IL-1alphabeta, TNF-alpha, IL-6), growth factors (IGF-I, TGF-beta, IRAP), physical performance and perceived function in total knee arthroplasty candidates (TKAC) (n=17) and healthy controls (n=21) was done. RESULTS: Serum IGF-I values were reduced in female (TKAC 137.6+/-7.2; Controls 160.2+/-26.2) but not male TKAC (TKAC 182.6+/-18.4; Controls 184.0+/-18.4) (p<0.05).). Serum and synovial levels of cytokines and growth factors did not differ significantly by group or gender. Physical performance testing (SPW, TUG) revealed significant group and gender differences (p=0.001) with women demonstrating greater functional impairment. DISCUSSION: A systemic, not local component to OA pathophysiology may exist for female TKAC. Male TKAC were less impaired, and their IGF-I levels differ little from Control values.
Authors: Alexander Y Hui; William J McCarty; Koichi Masuda; Gary S Firestein; Robert L Sah Journal: Wiley Interdiscip Rev Syst Biol Med Date: 2011-08-08
Authors: Jeffrey B Driban; Easwaran Balasubramanian; Mamta Amin; Michael R Sitler; Marvin C Ziskin; Mary F Barbe Journal: J Sport Rehabil Date: 2010-11 Impact factor: 1.931
Authors: Carsten P Bramlage; Thomas Häupl; Christian Kaps; Ute Ungethüm; Veit Krenn; Axel Pruss; Gerhard A Müller; Frank Strutz; Gerd-R Burmester Journal: Arthritis Res Ther Date: 2006-03-15 Impact factor: 5.156
Authors: Charles B Eaton; Maria Sayeed; Syeda Ameernaz; Mary B Roberts; John D Maynard; Jeffrey B Driban; Timothy E McAlindon Journal: Arthritis Res Ther Date: 2017-02-17 Impact factor: 5.156