BACKGROUND: Progression of hypertrophic cardiomyopathy (HCM) to left ventricular dilatation and systolic dysfunction sometimes occurs. However, the mechanism is not known. We examined whether oxidative stress was elevated in myocardia of HCM patients and whether the levels were correlated with left ventricular dilatation and systolic dysfunction. METHODS AND RESULTS: Endomyocardial biopsy samples obtained from the right ventricular side of the septum of 31 patients with HCM, and 10 control subjects were studied immunohistochemically for the expression of 4-hydroxy-2-nonenal (HNE)-modified protein, which is a major lipid peroxidation product. Expression of HNE-modified protein was found in all myocardial biopsy samples from patients with HCM. Expression was distinct in the cytosol of cardiomyocytes. The expression levels in patients with HCM were significantly increased compared with those in control subjects (P = .0005). The expression levels in patients with HCM were correlated with left ventricular end-diastolic diameter (r = 0.483, P = .0053) and end-systolic diameter (r = 0.500, P = .0037) determined by echocardiography. The expression levels were inversely correlated with left ventricular ejection fraction determined by left ventriculography (r = -0.640, P = .0001). CONCLUSION: Oxidative stress was elevated in myocardia of HCM patients and the levels were correlated with left ventricular dilatation and systolic dysfunction. Oxidative stress is involved in the pathogenesis of heart failure in patients with HCM.
BACKGROUND: Progression of hypertrophic cardiomyopathy (HCM) to left ventricular dilatation and systolic dysfunction sometimes occurs. However, the mechanism is not known. We examined whether oxidative stress was elevated in myocardia of HCM patients and whether the levels were correlated with left ventricular dilatation and systolic dysfunction. METHODS AND RESULTS: Endomyocardial biopsy samples obtained from the right ventricular side of the septum of 31 patients with HCM, and 10 control subjects were studied immunohistochemically for the expression of 4-hydroxy-2-nonenal (HNE)-modified protein, which is a major lipid peroxidation product. Expression of HNE-modified protein was found in all myocardial biopsy samples from patients with HCM. Expression was distinct in the cytosol of cardiomyocytes. The expression levels in patients with HCM were significantly increased compared with those in control subjects (P = .0005). The expression levels in patients with HCM were correlated with left ventricular end-diastolic diameter (r = 0.483, P = .0053) and end-systolic diameter (r = 0.500, P = .0037) determined by echocardiography. The expression levels were inversely correlated with left ventricular ejection fraction determined by left ventriculography (r = -0.640, P = .0001). CONCLUSION: Oxidative stress was elevated in myocardia of HCM patients and the levels were correlated with left ventricular dilatation and systolic dysfunction. Oxidative stress is involved in the pathogenesis of heart failure in patients with HCM.
Authors: Paul J M Wijnker; Vasco Sequeira; Diederik W D Kuster; Jolanda van der Velden Journal: Antioxid Redox Signal Date: 2018-04-11 Impact factor: 8.401
Authors: Styliani Vakrou; Ryuya Fukunaga; D Brian Foster; Lars Sorensen; Yamin Liu; Yufan Guan; Kirubel Woldemichael; Roberto Pineda-Reyes; Ting Liu; Jill C Tardiff; Leslie A Leinwand; Carlo G Tocchetti; Theodore P Abraham; Brian O'Rourke; Miguel A Aon; M Roselle Abraham Journal: JCI Insight Date: 2018-03-22
Authors: Katia M S Gomes; Luiz R G Bechara; Vanessa M Lima; Márcio A C Ribeiro; Juliane C Campos; Paulo M Dourado; Alicia J Kowaltowski; Daria Mochly-Rosen; Julio C B Ferreira Journal: Int J Cardiol Date: 2014-10-23 Impact factor: 4.164
Authors: Katia M S Gomes; Juliane C Campos; Luiz R G Bechara; Bruno Queliconi; Vanessa M Lima; Marie-Helene Disatnik; Paulo Magno; Che-Hong Chen; Patricia C Brum; Alicia J Kowaltowski; Daria Mochly-Rosen; Julio C B Ferreira Journal: Cardiovasc Res Date: 2014-05-09 Impact factor: 10.787
Authors: Elaine N Videan; Christopher B Heward; Kajal Chowdhury; John Plummer; Yali Su; Richard G Cutler Journal: Comp Med Date: 2009-06 Impact factor: 0.982