Literature DB >> 15728938

Mutational analysis of metronidazole resistance in Helicobacter pylori.

Jill M Moore1, Nina R Salama.   

Abstract

Metronidazole is one of a few antibiotics effective in eliminating Helicobacter pylori infection of the human stomach. Several chromosomal loci have been implicated in resistance to this drug. Saturation transposon mutagenesis of the H. pylori genome revealed inactivation of the rdxA gene as uniquely able to confer metronidazole resistance.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15728938      PMCID： PMC549284          DOI： 10.1128/AAC.49.3.1236-1237.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  A simple in vitro Tn7-based transposition system with low target site selectivity for genome and gene analysis.

Authors:  M C Biery; F J Stewart; A E Stellwagen; E A Raleigh; N L Craig
Journal:  Nucleic Acids Res       Date:  2000-03-01       Impact factor: 16.971

2.  Tagging exported proteins using Escherichia coli alkaline phosphatase gene fusions.

Authors:  C Manoil
Journal:  Methods Enzymol       Date:  2000       Impact factor: 1.600

3.  Global transposon mutagenesis and essential gene analysis of Helicobacter pylori.

Authors:  Nina R Salama; Benjamin Shepherd; Stanley Falkow
Journal:  J Bacteriol       Date:  2004-12       Impact factor: 3.490

4.  Vacuolating cytotoxin of Helicobacter pylori plays a role during colonization in a mouse model of infection.

Authors:  N R Salama; G Otto; L Tompkins; S Falkow
Journal:  Infect Immun       Date:  2001-02       Impact factor: 3.441

5.  Frequent association between alteration of the rdxA gene and metronidazole resistance in French and North African isolates of Helicobacter pylori.

Authors:  J Tankovic; D Lamarque; J C Delchier; C J Soussy; A Labigne; P J Jenks
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

6.  DNA sequence analysis of rdxA and frxA from 12 pairs of metronidazole-sensitive and -resistant clinical Helicobacter pylori isolates.

Authors:  D H Kwon; K Hulten; M Kato; J J Kim; M Lee; F A El-Zaatari; M S Osato; D Y Graham
Journal:  Antimicrob Agents Chemother       Date:  2001-09       Impact factor: 5.191

Review 7.  Mechanism and clinical significance of metronidazole resistance in Helicobacter pylori.

Authors:  E J van der Wouden; J C Thijs; J G Kusters; A A van Zwet; J H Kleibeuker
Journal:  Scand J Gastroenterol Suppl       Date:  2001

8.  Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase.

Authors:  A Goodwin; D Kersulyte; G Sisson; S J Veldhuyzen van Zanten; D E Berg; P S Hoffman
Journal:  Mol Microbiol       Date:  1998-04       Impact factor: 3.501

9.  Transformation of Helicobacter pylori by chromosomal metronidazole resistance and by a plasmid with a selectable chloramphenicol resistance marker.

Authors:  Y Wang; K P Roos; D E Taylor
Journal:  J Gen Microbiol       Date:  1993-10

10.  Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer.

Authors:  A Covacci; S Censini; M Bugnoli; R Petracca; D Burroni; G Macchia; A Massone; E Papini; Z Xiang; N Figura
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-15       Impact factor: 11.205
View more
  8 in total

1.  Search for novel candidate mutations for metronidazole resistance in Helicobacter pylori using next-generation sequencing.

Authors:  Tran Thanh Binh; Rumiko Suzuki; Tran Thi Huyen Trang; Dong Hyeon Kwon; Yoshio Yamaoka
Journal:  Antimicrob Agents Chemother       Date:  2015-02-02       Impact factor: 5.191

2.  Mechanisms of Helicobacter pylori antibiotic resistance: An updated appraisal.

Authors:  Vincenzo De Francesco; Angelo Zullo; Cesare Hassan; Floriana Giorgio; Rosa Rosania; Enzo Ierardi
Journal:  World J Gastrointest Pathophysiol       Date:  2011-06-15

3.  Helicobacter pylori therapy: Present and future.

Authors:  Vincenzo De Francesco; Enzo Ierardi; Cesare Hassan; Angelo Zullo
Journal:  World J Gastrointest Pharmacol Ther       Date:  2012-08-06

4.  Recent Insights into Antibiotic Resistance in Helicobacter pylori Eradication.

Authors:  Wenming Wu; Yunsheng Yang; Gang Sun
Journal:  Gastroenterol Res Pract       Date:  2012-07-05       Impact factor: 2.260

5.  Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China.

Authors:  Yong Xie; Zhenhua Zhu; Jiangbin Wang; Lingxia Zhang; Zhenyu Zhang; Hong Lu; Zhirong Zeng; Shiyao Chen; Dongsheng Liu; Nonghua Lv
Journal:  Antimicrob Agents Chemother       Date:  2018-08-27       Impact factor: 5.191

6.  A versatile medium for cultivating methanogenic archaea.

Authors:  Saber Khelaifia; Didier Raoult; Michel Drancourt
Journal:  PLoS One       Date:  2013-04-17       Impact factor: 3.240

7.  Comparison of Culture With Antibiogram to Next-Generation Sequencing Using Bacterial Isolates and Formalin-Fixed, Paraffin-Embedded Gastric Biopsies.

Authors:  Kristina G Hulten; Robert M Genta; Ira N Kalfus; Yi Zhou; Hongjun Zhang; David Y Graham
Journal:  Gastroenterology       Date:  2021-07-19       Impact factor: 33.883

8.  Analysis of core protein clusters identifies candidate variable sites conferring metronidazole resistance in Helicobacter pylori.

Authors:  Eng-Guan Chua; Aleksandra W Debowski; K Mary Webberley; Fanny Peters; Binit Lamichhane; Mun-Fai Loke; Jamuna Vadivelu; Chin-Yen Tay; Barry J Marshall; Michael J Wise
Journal:  Gastroenterol Rep (Oxf)       Date:  2019-01-02
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.