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Literature DB >> 15723441

Design, synthesis and antimalarial activity of trifluoromethylartemisinin-mefloquine dual molecules.

Fabienne Grellepois¹, Philippe Grellier, Danièle Bonnet-Delpon, Jean-Pierre Bégué.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2005 PMID： 15723441 DOI： 10.1002/cbic.200400347

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

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12 in total

Review 1. Are Antimalarial Hybrid Molecules a Close Reality or a Distant Dream?

Authors: Drishti Agarwal; Rinkoo D Gupta; Satish K Awasthi
Journal: Antimicrob Agents Chemother Date: 2017-04-24 Impact factor: 5.191

2. Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy.

Authors: Rita Capela; Ghislain G Cabal; Philip J Rosenthal; Jiri Gut; Maria M Mota; Rui Moreira; Francisca Lopes; Miguel Prudêncio
Journal: Antimicrob Agents Chemother Date: 2011-08-01 Impact factor: 5.191

3. A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) Is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis.

Authors: Caroline De Souza Pereira; Helenita Costa Quadros; Samuel Yaw Aboagye; Diana Fontinha; Sarah D'Alessandro; Margaret Elizabeth Byrne; Mathieu Gendrot; Isabelle Fonta; Joel Mosnier; Diogo Rodrigo M Moreira; Nicoletta Basilico; David L Williams; Miguel Prudêncio; Bruno Pradines; Maribel Navarro
Journal: Pharmaceutics Date: 2022-06-12 Impact factor: 6.525

Review 4. 1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agents.

Authors: Didier Belorgey; Don Antoine Lanfranchi; Elisabeth Davioud-Charvet
Journal: Curr Pharm Des Date: 2013 Impact factor: 3.116

Review 5. Targeting lipid biosynthesis and salvage in apicomplexan parasites for improved chemotherapies.

Authors: Isabelle Coppens
Journal: Nat Rev Microbiol Date: 2013-10-28 Impact factor: 60.633

6. Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids.

Authors: Marli C Lombard; David D N'Da; Christophe Tran Van Ba; Sharon Wein; Jennifer Norman; Lubbe Wiesner; Henri Vial
Journal: Malar J Date: 2013-02-21 Impact factor: 2.979

Design, synthesis and antimalarial activity of trifluoromethylartemisinin-mefloquine dual molecules.

Review 1. Are Antimalarial Hybrid Molecules a Close Reality or a Distant Dream?

2. Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy.

3. A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) Is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis.

Review 4. 1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agents.

Review 5. Targeting lipid biosynthesis and salvage in apicomplexan parasites for improved chemotherapies.

6. Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids.

7. 1-Bromo-2-(10β-dihydro-artemisin-oxy)ethane.

8. Benzyl 2-{[2,8-bis-(trifluoro-meth-yl)quinolin-4-yl](hy-droxy)meth-yl}piperidine-1-carboxyl-ate.

9. tert-Butyl 2-{[2,8-bis-(trifluoro-meth-yl)quinolin-4-yl](hy-droxy)meth-yl}piperidine-1-carboxyl-ate.

10. Efficacy and safety evaluation of a novel trioxaquine in the management of cerebral malaria in a mouse model.