Literature DB >> 15722080

Identification and disruption of a rhoptry-localized homologue of sodium hydrogen exchangers in Toxoplasma gondii.

Ariela O Karasov1, John C Boothroyd, Gustavo Arrizabalaga.   

Abstract

Na+/H+ exchangers (NHEs) are ubiquitous membrane proteins that catalyze the exchange of Na+ for H+ and are critical in pH and cell volume regulation, as well as osmotolerance. In this study, we identify and characterize a novel NHE, TgNHE2, in Toxoplasma gondii. Immunofluorescence studies show that TgNHE2 is localized to the rhoptries, secretory organelles involved in invasion. TgNHE2 is the first intracellular NHE to be characterized in a protozoan parasite and its localization suggests possible roles for the rhoptries in osmotolerance and/or as secretory lysosomes-like granules.

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Year:  2005        PMID： 15722080     DOI： 10.1016/j.ijpara.2004.11.015

Source DB:  PubMed          Journal:  Int J Parasitol        ISSN： 0020-7519            Impact factor:   3.981


  18 in total

1.  SPM1 stabilizes subpellicular microtubules in Toxoplasma gondii.

Authors:  Johnson Q Tran; Catherine Li; Alice Chyan; Lawton Chung; Naomi S Morrissette
Journal:  Eukaryot Cell       Date:  2011-10-21

2.  Toxoplasma gondii targets a protein phosphatase 2C to the nuclei of infected host cells.

Authors:  Luke A Gilbert; Sandeep Ravindran; Jay M Turetzky; John C Boothroyd; Peter J Bradley
Journal:  Eukaryot Cell       Date:  2006-11-03

3.  Intervacuolar transport and unique topology of GRA14, a novel dense granule protein in Toxoplasma gondii.

Authors:  Michael E Rome; Josh R Beck; Jay M Turetzky; Paul Webster; Peter J Bradley
Journal:  Infect Immun       Date:  2008-09-02       Impact factor: 3.441

4.  Use of the kinase inhibitor analog 1NM-PP1 reveals a role for Toxoplasma gondii CDPK1 in the invasion step.

Authors:  Tatsuki Sugi; Kentaro Kato; Kyosuke Kobayashi; Shumpei Watanabe; Hitomi Kurokawa; Haiyan Gong; Kishor Pandey; Hitoshi Takemae; Hiroomi Akashi
Journal:  Eukaryot Cell       Date:  2010-02-19

5.  Processing and secretion of ROP13: A unique Toxoplasma effector protein.

Authors:  Jay M Turetzky; David K Chu; Bettina E Hajagos; Peter J Bradley
Journal:  Int J Parasitol       Date:  2010-03-30       Impact factor: 3.981

6.  Molecular dissection of novel trafficking and processing of the Toxoplasma gondii rhoptry metalloprotease toxolysin-1.

Authors:  Bettina E Hajagos; Jay M Turetzky; Eric D Peng; Stephen J Cheng; Christopher M Ryan; Puneet Souda; Julian P Whitelegge; Maryse Lebrun; Jean-Francois Dubremetz; Peter J Bradley
Journal:  Traffic       Date:  2011-11-29       Impact factor: 6.215

7.  RNG1 is a late marker of the apical polar ring in Toxoplasma gondii.

Authors:  Johnson Q Tran; Jessica C de Leon; Catherine Li; My-Hang Huynh; Wandy Beatty; Naomi S Morrissette
Journal:  Cytoskeleton (Hoboken)       Date:  2010-09

8.  Identification of three novel Toxoplasma gondii rhoptry proteins.

Authors:  Ana Camejo; Daniel A Gold; Diana Lu; Kiva McFetridge; Lindsay Julien; Ninghan Yang; Kirk D C Jensen; Jeroen P J Saeij
Journal:  Int J Parasitol       Date:  2013-09-24       Impact factor: 3.981

9.  The FIKK kinase of Toxoplasma gondii is not essential for the parasite's lytic cycle.

Authors:  S Skariah; O Walwyn; K Engelberg; M-J Gubbels; C Gaylets; N Kim; B Lynch; A Sultan; D G Mordue
Journal:  Int J Parasitol       Date:  2016-02-06       Impact factor: 3.981

10.  A novel family of Toxoplasma IMC proteins displays a hierarchical organization and functions in coordinating parasite division.

Authors:  Josh R Beck; Imilce A Rodriguez-Fernandez; Jessica Cruz de Leon; My-Hang Huynh; Vern B Carruthers; Naomi S Morrissette; Peter J Bradley
Journal:  PLoS Pathog       Date:  2010-09-09       Impact factor: 6.823
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