BACKGROUND: Granulosa cell tumors of the ovary are rare, primarily treated surgically. In advanced or recurrent disease, data are inconclusive regarding the benefit of either primary or adjuvant chemotherapy. Hormonal therapy has been suggested as an alternative treatment. CASE: Our patient had three recurrences of estrogen receptor negative and progesterone receptor positive GCT, the first two treated by surgery with or without adjuvant chemotherapy. For the third recurrence, the patient received alternating biweekly cycles of megestrol and tamoxifen. Computed tomography showed stable disease at 6 months, partial response at 18 months, and complete response at 22 months. The patient continues on hormonal therapy and has been disease-free for 5 years. CONCLUSION: This study and others suggest that hormonal therapy may provide another option for treating these relatively rare tumors.
BACKGROUND:Granulosa cell tumors of the ovary are rare, primarily treated surgically. In advanced or recurrent disease, data are inconclusive regarding the benefit of either primary or adjuvant chemotherapy. Hormonal therapy has been suggested as an alternative treatment. CASE: Our patient had three recurrences of estrogen receptor negative and progesterone receptor positive GCT, the first two treated by surgery with or without adjuvant chemotherapy. For the third recurrence, the patient received alternating biweekly cycles of megestrol and tamoxifen. Computed tomography showed stable disease at 6 months, partial response at 18 months, and complete response at 22 months. The patient continues on hormonal therapy and has been disease-free for 5 years. CONCLUSION: This study and others suggest that hormonal therapy may provide another option for treating these relatively rare tumors.
Authors: Jane L Meisel; David M Hyman; Anjali Jotwani; Qin Zhou; Nadeem R Abu-Rustum; Alexia Iasonos; Malcolm C Pike; Carol Aghajanian Journal: Gynecol Oncol Date: 2014-12-26 Impact factor: 5.482
Authors: Florian Viehweger; Lisa-Marie Tinger; David Dum; Natalia Gorbokon; Anne Menz; Ria Uhlig; Franziska Büscheck; Andreas M Luebke; Claudia Hube-Magg; Andrea Hinsch; Doris Höflmayer; Christoph Fraune; Patrick Lebok; Sören Weidemann; Maximilian Lennartz; Frank Jacobsen; Till S Clauditz; Rainer Krech; Till Krech; Andreas H Marx; Ronald Simon; Eike Burandt; Stefan Steurer; Guido Sauter; Sarah Minner; Christian Bernreuther Journal: Anal Cell Pathol (Amst) Date: 2022-08-08 Impact factor: 4.133