Literature DB >> 15719120

Saccharin as a salt former. Enhanced solubilities of saccharinates of active pharmaceutical ingredients.

Prashant M Bhatt1, Nittala V Ravindra, Rahul Banerjee, Gautam R Desiraju.   

Abstract

Saccharin, acting as a weak acid, forms salts with basic APIs and these salts have the desirable property of enhanced water solubility.

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Year:  2005        PMID： 15719120     DOI： 10.1039/b416137h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

1.  Micellar solubilization of some poorly soluble antidiabetic drugs: a technical note.

Authors:  Neelam Seedher; Mamta Kanojia
Journal:  AAPS PharmSciTech       Date:  2008-03-05       Impact factor: 3.246

2.  Detection of cocrystal formation based on binary phase diagrams using thermal analysis.

Authors:  Hiroyuki Yamashita; Yutaka Hirakura; Masamichi Yuda; Toshio Teramura; Katsuhide Terada
Journal:  Pharm Res       Date:  2012-08-21       Impact factor: 4.200

3.  Mechanochemical synthesis insights and solid-state characterization of quininium aspirinate, a glass-forming drug-drug salt.

Authors:  Nehemiah Harris; Jubilee Benedict; Diane A Dickie; Silvina Pagola
Journal:  Acta Crystallogr C Struct Chem       Date:  2021-08-25       Impact factor: 1.184

Review 4.  Cocrystals to facilitate delivery of poorly soluble compounds beyond-rule-of-5.

Authors:  Gislaine Kuminek; Fengjuan Cao; Alanny Bahia de Oliveira da Rocha; Simone Gonçalves Cardoso; Naír Rodríguez-Hornedo
Journal:  Adv Drug Deliv Rev       Date:  2016-04-29       Impact factor: 15.470

5.  Pharmaceutical Cocrystals and Their Physicochemical Properties.

Authors:  Nate Schultheiss; Ann Newman
Journal:  Cryst Growth Des       Date:  2009-04-20       Impact factor: 4.076

6.  New Saccharin Salt of Chlordiazepoxide: Structural and Physicochemical Examination.

Authors:  Anna Lech; Patrycja Garbacz; Artur Sikorski; Maria Gazda; Marek Wesolowski
Journal:  Int J Mol Sci       Date:  2022-10-10       Impact factor: 6.208

7.  Acemetacin cocrystals and salts: structure solution from powder X-ray data and form selection of the piperazine salt.

Authors:  Palash Sanphui; Geetha Bolla; Ashwini Nangia; Vladimir Chernyshev
Journal:  IUCrJ       Date:  2014-02-28       Impact factor: 4.769

8.  Solubility Improvement of Benexate through Salt Formation Using Artificial Sweetener.

Authors:  Okky Dwichandra Putra; Daiki Umeda; Eriko Fujita; Tamami Haraguchi; Takahiro Uchida; Etsuo Yonemochi; Hidehiro Uekusa
Journal:  Pharmaceutics       Date:  2018-05-26       Impact factor: 6.321
  8 in total

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