| Literature DB >> 15716910 |
Emmanouil T Dermitzakis1, Alexandre Reymond, Stylianos E Antonarakis.
Abstract
Mammalian genomes contain highly conserved sequences that are not functionally transcribed. These sequences are single copy and comprise approximately 1-2% of the human genome. Evolutionary analysis strongly supports their functional conservation, although their potentially diverse, functional attributes remain unknown. It is likely that genomic variation in conserved non-genic sequences is associated with phenotypic variability and human disorders. So how might their function and contribution to human disorders be examined?Entities:
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Year: 2005 PMID： 15716910 DOI： 10.1038/nrg1527
Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242